Background: Neurocysticercosis (NCC), a common cause of seizures in children from low and middle income countries (LMICs), if not diagnosed and treated early enough may lead to considerable morbidity and mortality. There is a lack of data on the prevalence of NCC and its clinical characteristics among those with seizure in South-Western Nepal.
Aims And Objectives: To study the prevalence and clinical characteristics of NCC in children with seizures.
Material And Methods: All children admitted to Universal College of Medical Sciences, a tertiary hospital in South-Western Nepal with seizures during 2014-16, were tested for NCC. NCC was diagnosed by neuroimaging [computerized tomography (CT) scan or magnetic resonance imaging (MRI)]. We used logistic regression to test the association between NCC with participants' characteristics and clinical symptoms.
Results: Among 4962 in-patient children, 168 (104 boys and 64 girls) had seizures (138 with generalized tonic clonic seizures (GTCS) and 30 with focal seizures). 43% of children with seizures had CT scan confirmed NCC. The prevalence of NCC in the oldest children (13-16 years) was significantly greater (57.1% versus 15.6%) compared to the youngest (0-4 years) one ( < 0.001). Among 72 children with NCC, the proportions of children with vesicular, calcified, and colloidal stages were 76% ( = 35), 18% ( = 13), and 6% ( = 2), respectively. Children with focal seizures had 13% more NCC compared to those with GTCS but the result was statistically not significant. The adjusted odds of having NCC among 5-8 years, 9-12 years, and 13-16 years children were 6.6 (1.78-24.60), 11.06 (2.74-44.60), and 14.47 (3.13-66.96), respectively, compared to 0-4-year-old children. Reoccurrence of seizures within the first 3 months of taking antiepileptic drug in those with NCC was approximately 3 times higher compared to those without NCC (11% versus 4%, = 0.084).
Conclusions: This study shows that NCC contributes significantly to higher prevalence of seizures in children in South-Western region of Nepal.
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http://dx.doi.org/10.1155/2018/1030878 | DOI Listing |
Polymers (Basel)
December 2024
Department of Biomedical Engineering, Pamukkale University, Denizli 20160, Türkiye.
Bio-nanomaterials are gaining increasing attention due to their renewable and eco-friendly characteristics. Among these, nanocrystalline cellulose (NCC) stands out as one of the most advanced materials for applications in food, healthcare, composite production, and beyond. In this study, NCC was successfully extracted from cotton-based textile waste using a combination of chemical and mechanical methods.
View Article and Find Full Text PDFChemistry
January 2025
The University of British Columbia, Department of Chemistry, 2036 Main Mall, V6T 1Z1, Vancouver, CANADA.
The field of platinum chemistry is ubiquitous in the research of anticancer drugs and new OLED materials. Within the vast library of existing compounds, the majority of work focuses on complexes in the +2 and +4 oxidation states, with comparatively few examples of PtIII complexes reported without bridging ligands. PtIII complexes with metal-metal bonding can be made by mild oxidation of PtII complexes having bis(phenylpyridine) ligands.
View Article and Find Full Text PDFNat Commun
January 2025
Division of Genome Analysis Platform Development, National Cancer Center Research Institute, Tokyo, Japan.
Genomic variants causing abnormal splicing play important roles in genetic disorders and cancer development. Among them, variants that cause the formation of novel splice-sites (splice-site creating variants, SSCVs) are particularly difficult to identify and often overlooked in genomic studies. Additionally, these SSCVs are frequently considered promising candidates for treatment with splice-switching antisense oligonucleotides (ASOs).
View Article and Find Full Text PDFBMC Public Health
January 2025
Department of Epidemiology and Prevention, Center for Clinical Sciences, National Center for Global Health and Medicine, 1-21-1 Toyama, Shinjuku-ku, Tokyo, 162-8655, Japan.
Background: While previous literature suggests that multimorbidity is linked to a higher risk of mortality, evidence is scarce among individuals in middle adulthood. We aimed to examine the association between physical multimorbidity and all-cause mortality among individuals aged 40-64 years at baseline in Japan.
Methods: Data were obtained from two cohort studies, the Japan Public Health Center-based Prospective Study (JPHC) and the Japan Epidemiology Collaboration on Occupational Health Study (J-ECOH).
Int J Biol Macromol
January 2025
Faculty of Chemistry, Northeast Normal University, 5268 Renmin Street, Changchun 130024, PR China; College of Chemical Engineering, Changchun University of Technology, 2055 Yanan Street, Changchun 130024, PR China. Electronic address:
Solid polymer batteries (SPEs) are highly desirable for energy storage because of the urgent need for higher energy density and safer lithium ion batteries (LIBs). In this work, the single-ion lithium salt PAEK-LiCPSI was synthesized by grafting 3-chloropropanesulfonyl trifluoromethanesulimide lithium (LiCPSI) onto poly(aryl ether ketone) (PAEK). Nanocellulose (NCC), PAEK-LiCPSI, and poly(vinylidene fluoride) (PVDF-HFP) were compounded to obtain NCC reinforced high-performance nanofiber composite polymer electrolytes (NCC/PAEK/PVDF) through electrospinning, which presented tensile strength of 15.
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