AI Article Synopsis
- Four inhaler adherence clusters were identified in COPD patients: regular use with good technique, regular use with technique errors, irregular use with good technique, and irregular use with technique errors.
- The study estimates the cost-effectiveness of improving adherence by shifting patients from clusters 2, 3, and 4 to the optimal cluster of regular use with good technique over a 5-year period in the Irish healthcare context.
- Interventions for adherence could lead to increased quality-adjusted life years, particularly showing the best cost-effectiveness in cluster 3, which could result in annual savings of €845 per person.
Article Abstract
Four inhaler adherence clusters have been identified using the INCA audio device in COPD patients: (1) regular use/good technique, (2) regular use/frequent technique errors, (3) irregular use/good technique, and (4) irregular use/frequent technique errors. Their relationship with healthcare utilization and mortality was established, but the cost-effectiveness of adherence-enhancing interventions is unknown. In this exploratory study, we aimed to estimate the potential cost-effectiveness of reaching optimal adherence in the three suboptimal adherence clusters, i.e., a theoretical shift of clusters 2, 3, and 4 to cluster 1. Cost-effectiveness was estimated over a 5-year time horizon using the Irish healthcare payer perspective. We used a previously developed COPD health-economic model that was updated with INCA trial data and Irish national economic and epidemiological data. For each cluster, interventions would result in additional quality-adjusted life years gained at reasonable investment. Cost-effectiveness was most favorable in cluster 3, with possible cost savings of €845/annum/person.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6021429 | PMC |
| http://dx.doi.org/10.1038/s41533-018-0092-8 | DOI Listing |
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