Objective: To evaluate the association of obesity with Gleason scores determined in biopsy and radical prostatectomy specimens.
Study Design: Cohort study.
Place And Duration Of Study: Urology Department, Fatih Sultan Mehmet Research Hospital, Istanbul, Turkey from 2007 to 2015.
Methodology: A total of 111 patients, younger than 65 years who underwent radical prostatectomy (RP) with the diagnosis of prostate cancer, were included in the study. Histopathology reports of the surgical, and TRUS-guided prostate biopsy specimens were analysed. Body mass index (BMI) and prostate specific antigen (PSA) levels were also evaluated.
Results: Mean age of the patients was 59.06 ±4.10 (range = 47-64 years) years. Mean BMI of the patients was 25.59 ±3.24 kg/m2 (range = 19-35 kg/m2). In patients whose BMI measurements were equal or above 25 kg/m2; a significant difference was found between Gleason scores of the needle biopsy and RP specimens (p=0.001).
Conclusion: BMI and PSA, which are known to be the most important parameters effecting Gleason score, were evaluated in combination. Regarding non-concordance with Gleason scores, it has been observed that as a predisposing factor, obesity can explain these incompatibilities similarly to PSA.
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| http://dx.doi.org/10.29271/jcpsp.2018.07.541 | DOI Listing |
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