AI Article Synopsis
- Addiction is a chronic disorder where individuals compulsively use substances, and current medical treatments often lack effectiveness.
- Emerging research suggests that neuropeptides, particularly galanin, could offer new therapeutic targets for treating addiction.
- The review also explores the roles of other neuropeptides like orexin and dynorphin in influencing reward-seeking behavior in relation to substance abuse.
Article Abstract
Addiction is a chronic, relapsing disorder characterised by the use of a substance or act to the point of compulsion. There are a number of medical treatments available for the intervention of these disorders, however, the effectiveness of current therapeutics is far from adequate. Neuropeptides are known to modulate addictive behaviours and may provide new therapeutic targets for the treatment of substance abuse. Accumulating evidence has suggested galanin as a potential important neuromodulator of addiction. Both human genetic studies and animal models have highlighted a role for this neuropeptide in affective disorders, as well as alcohol, nicotine, and opiate dependence. This review highlights the role of galanin and other primary neuropeptides implicated in modulating addiction to different drugs of abuse. Orexin, relaxin-3, corticotrophin-releasing factor, dynorphin and enkephalin, are also discussed given their involvement in mediating reward-seeking behaviour.
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| http://dx.doi.org/10.1016/j.neubiorev.2018.06.021 | DOI Listing |
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