AI Article Synopsis
- The study aims to compare the effects of hypotonic and isotonic riboflavin solutions on the depth of the demarcation line (DDL) in the cornea during accelerated corneal cross-linking (CXL) for keratoconus patients.
- In this study, 38 eyes from 26 patients were analyzed, with Group 1 receiving hypotonic riboflavin for thinner corneas (under 400 µm) and Group 2 receiving isotonic riboflavin for thicker corneas (over 400 µm).
- The results showed a significant difference in DDL between the two groups after one month, with Group 1 averaging 180.32 µm and Group 2 averaging 287.21
Article Abstract
Purpose: The aim of this study is to compare the effect of different riboflavin solutions (hypotonic and isotonic) used during accelerated corneal cross-linking (CXL) on the mean depth of the demarcation line (DDL) formed in corneal stroma.
Methods: This prospective, cross-sectional study included 38 eyes of 26 patients. All patients underwent accelerated CXL due to progressive keratoconus. When the corneal epithelium was removed, 17 eyes of 12 patients with corneal thickness < 400 µm were categorized as Group 1, and 21 eyes of 14 patients with corneal thickness > 400 µm as Group 2. Hypotonic riboflavin was applied to Group 1 patients, and isotonic riboflavin to Group 2 patients. Anterior segment optical coherence tomography was performed on all patients by two independent observers at the end of the first and third months.
Result: Group 1 included 5 male and 7 female patients with an average age of 25.1 ± 8.0 years, whereas Group 2 included 7 male and 7 female patients with an average age of 31.8 ± 10.12 years. At the end of the first month, the mean DDL in Group 1 and Group 2 was 180.32 ± 10.26 and 287.21 ± 15.01 µm, respectively. This difference was statistically significant (p < 0.05).
Conclusion: Application of different riboflavin solutions was observed to have an effect on measured corneal thickness after saturation and the depth of the demarcation line. The use of hypotonic riboflavin results in swelling of the cornea and more superficial localization of the stromal demarcation line after CXL.
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| http://dx.doi.org/10.1007/s10792-018-0951-x | DOI Listing |
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