AI Article Synopsis
- The MHC class I glycoproteins BF2 and BF1 in chickens differ in their ability to present viral antigens and interact with immune cells.
- Cytotoxic T lymphocytes can recognize viral antigens presented by the BF2 glycoprotein but not by BF1, indicating BF2's primary role in antigen presentation.
- While Marek's disease virus decreases BF2 expression, it does not significantly affect BF1, which helps protect cells from NK cell lysis, showcasing their distinct immune functions.
Article Abstract
The function of the chicken's major histocompatibility complex (MHC or B complex) class I major (BF2) and minor (BF1) glycoproteins is compared for their expression, ability to present viral antigens to cytotoxic T lymphocytes (CTLs), and interaction with natural killer (NK) cells. MHC-restricted CTLs recognized virus antigen in the context of the BF2*21 major glycoprotein but not the BF1*21 minor glycoprotein. Marek's disease virus (MDV), a large DNA virus known to reduce the cell surface expression of class I glycoprotein, reduced the expression of BF2 glycoprotein while BF1glycoprotein expressions are remained as no change or slight increase. In addition, the expression of BF1*21 class I glycoprotein protected target cells from NK cell lysis while the expression of the BF2*21 class I glycoprotein enhanced NK cell lysis of target cells. Therefore, BF1 and BF2 provide two different cellular immune functions; BF1 negatively regulates the NK cell killing activity and BF2 restricts the antigen specific CTL immune response.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1007/s00251-018-1066-2 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!