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The First Report of -1-Carrying , Isolated from a Clinical Sample in the North-East of Romania.
Microorganisms
November 2024
Department of Microbiology, Faculty of Medicine, "Grigore T. Popa" University of Medicine and Pharmacy, 16 Universitatii Street, 700115 Iași, Romania.
Colistin resistance poses a significant clinical challenge, particularly in Gram-negative bacteria. This study investigates the occurrence of plasmid-mediated colistin resistance among isolates (, , and spp.) and non-fermentative rods ( and ).
View Article and Find Full Text PDFNo genetic link between E. coli isolates carrying mcr-1 in bovines and humans in France.
J Glob Antimicrob Resist
January 2025
Institut National de la Santé et de la Recherche Médicale (UMR 1071), Institut National de la Recherche Agronomique (USC-2018), Université Clermont Auvergne, Clermont-Ferrand, France; Centre National de Référence de la Résistance aux Antibiotiques, Centre Hospitalier Universitaire, Clermont-Ferrand, France.
Background: Colistin is a last-line antibiotic used to treat severe human infections caused by carbapenemase-producing Gram-negative bacteria. In parallel, colistin has massively been used in the veterinary field so that mcr-1-positive E. coli have spread worldwide in livestock, potentially constituting a reservoir of colistin-resistant isolates that can be further transmitted to humans.
View Article and Find Full Text PDFPrevalence, transmission and genomic epidemiology of mcr-1-positive colistin-resistant Escherichia coli strains isolated from international airplane waste, local resident fecal and wastewater treatment plants.
Sci Total Environ
December 2024
Shanghai Municipal Center for Disease Control and Prevention, Shanghai, China. Electronic address:
Article Synopsis
- The study analyzes the prevalence and genetic characteristics of mcr-1-positive Escherichia coli (MCRPEC) from various sources such as wastewater treatment plants (WWTPs), local residents’ fecal samples, and international airplane waste, highlighting significant public health risks.
- Findings reveal a 2.43% prevalence in WWTPs, 1.37% in airplane waste, and 0.69% in local fecal samples, with the MCRPEC showing high genetic diversity and a significant number of antibiotic resistance and virulence factor genes.
- The results indicate widespread transmission and environmental adaptation of MCRPEC, emphasizing the urgent need for inclusive surveillance to tackle this emerging health threat effectively.
High prevalence of multidrug-resistant Escherichia coli in retail aquatic products in China and the first report of mcr-1-positive extended-spectrum β-lactamase-producing E. coli ST2705 and ST10 in fish.
Int J Food Microbiol
October 2023
Guangdong Provincial Key Laboratory of Microbial Safety and Health, State Key Laboratory of Applied Microbiology Southern China, Ministry of Agriculture and Rural Affairs, Institute of Microbiology, Guangdong Academy of Sciences, Guangzhou, Guangdong Province 510070, China.
Article Synopsis
- Contamination of retail aquatic products in China by multidrug-resistant (MDR) E. coli poses a significant health risk to consumers, with 40% of samples found to contain E. coli and 19.9% showing resistance to multiple drugs.
- The study analyzed 849 samples from fish, shrimp, and shellfish across 39 cities and revealed high levels of antibiotic resistance, especially to tetracycline and trimethoprim-sulfamethoxazole.
- A variety of antibiotic resistance genes were identified, with a concerning prevalence of resistant strains, including colistin-resistant isolates associated with the mcr-1 gene, highlighting poor hygiene practices in retail markets.
Convergence of mcr-1 and broad-spectrum β-lactamase genes in Escherichia coli strains from the environmental sector.
Environ Pollut
December 2024
Department of Clinical Analyses, Toxicology and Food Science, School of Pharmaceutical Sciences of Ribeirão Preto, University of São Paulo, Ribeirão Preto, São Paulo, Brazil. Electronic address:
The mcr-type gene encodes the main plasmid-mediated mechanism of colistin resistance and has been reported in several bacterial species obtained from different sources. Anthropogenic activities in the environment favor the evolution of antimicrobial resistance. Indeed, mcr-1-positive Escherichia coli strains were susceptible to non-polymyxins antimicrobials, but now emerging as multidrug-resistant (MDR) lineages.
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