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An Ear Mystery: Conductive Hearing Loss with Normal Acoustic Reflexes and VEMPs.
Laryngoscope
October 2024
Department of Otolaryngology-Head & Neck Surgery, University of California - San Francisco, San Francisco, California, U.S.A.
The cause of sudden conductive loss in the absences of other vestibulo-audiologic abnormalities can be isolated to specific subsites of the ossicular chain using audiometric testing. In the absence of such abnormalities, a rare etiology may be the cause after an inciting trauma. Laryngoscope, 134:4344-4346, 2024.
View Article and Find Full Text PDFNonquantal transmission at the vestibular hair cell-calyx synapse: K currents modulate fast electrical and slow K potentials.
Proc Natl Acad Sci U S A
January 2023
Department of Bioengineering, Rice University, Houston, TX 77005.
Vestibular hair cells transmit information about head position and motion across synapses to primary afferent neurons. At some of these synapses, the afferent neuron envelopes the hair cell, forming an enlarged synaptic terminal called a calyx. The vestibular hair cell-calyx synapse supports a mysterious form of electrical transmission that does not involve gap junctions, termed nonquantal transmission (NQT).
View Article and Find Full Text PDFDifferences in the Structure and Function of the Vestibular Efferent System Among Vertebrates.
Front Neurosci
June 2021
Department of Biomedical Engineering, Johns Hopkins University, Baltimore, MD, United States.
The role of the mammalian vestibular efferent system in everyday life has been a long-standing mystery. In contrast to what has been reported in lower vertebrate classes, the mammalian vestibular efferent system does not appear to relay inputs from other sensory modalities to the vestibular periphery. Furthermore, to date, the available evidence indicates that the mammalian vestibular efferent system does not relay motor-related signals to the vestibular periphery to modulate sensory coding of the voluntary self-motion generated during natural behaviors.
View Article and Find Full Text PDFThe real identity and sensory overlap mechanism of special vestibular afferent neurons that sense both rotation and linear force.
Life Sci
October 2020
Department of Otolaryngology-Head & Neck Surgery, The First Affiliated Hospital of Xi'an Jiaotong University, 227 Yanta West Roud, Xi'an, Shaanxi 710061, China. Electronic address:
Aims: Although the vestibular system has been widely investigated over the past 50 years, there is still an unsolved mystery. Some special vestibular afferent (SVA) neurons responding to both rotation and linear force were found through neurophysiological techniques, however, the sensory overlap mechanism of SVA neurons is still unclear, which may be closely related to vestibular-related diseases.
Materials And Methods: To address the above-mentioned problem, a cupula buoyancy theory was established in the present study, where SVA neurons were considered semicircular canal afferent (SCCA) neurons.
Nanocompartmentalization of the Nuclear Pore Lumen.
Biophys J
January 2020
Department of Biomedical Engineering, Northwestern University, Evanston, Illinois; Department of Chemistry, and Chemistry of Life Processes Institute, Northwestern University, Evanston, Illinois. Electronic address:
The nuclear pore complex (NPC) employs the intrinsically disordered regions (IDRs) from a family of phenylalanine-glycine-rich nucleoporins (FG-Nups) to control nucleocytoplasmic transport. It has been a long-standing mystery how the IDR-mediated mass exchange can be rapid yet selective. Here, we use a computational microscope to show that nanocompartmentalization of IDR subdomains leads to a remarkably elaborate gating structure as programmed by the amino acid sequences.
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