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Repeat and haplotype aware error correction in nanopore sequencing reads with DeChat.
Commun Biol
December 2024
College of Biology, Hunan University, Changsha, China.
Error self-correction is crucial for analyzing long-read sequencing data, but existing methods often struggle with noisy data or are tailored to technologies like PacBio HiFi. There is a gap in methods optimized for Nanopore R10 simplex reads, which typically have error rates below 2%. We introduce DeChat, a novel approach designed specifically for these reads.
View Article and Find Full Text PDFThe synergistic effect of combining botulinum toxin with polydioxanone threads on the upper face static wrinkles.
Arch Dermatol Res
December 2024
Dermatology, Venereology and Andrology Department, Faculty of Medicine, Zagazig University, Zagazig, Egypt.
With aging, facial lines on the forehead and glabella are sometimes converted from dynamic to static giving an aged appearance. Polydioxanone sutures are popular now as a management option in correcting deep static wrinkles on the upper face .This work was conducted to assess the synergistic efficacy of combining Botulinum toxin injection with Polydioxanone threads on the upper face static wrinkles.
View Article and Find Full Text PDFBackground: Glycolic acid (GA) is an α-hydroxy peeling agent that causes controlled removal of the epidermis, with or without the dermis. Studies have shown the ability of GA to stimulate fibroblast proliferation, induce collagen synthesis, and decrease collagen degradation. The VoluDerm radiofrequency microneedling (RFMN; Pollogen, Tel Aviv, Israel) utilizes an array of microelectrodes to penetrate the epidermis and deliver energy to the skin.
View Article and Find Full Text PDFInnovative gene delivery systems for retinal disease therapy.
Neural Regen Res
December 2024
Department of Ophthalmology, Songjiang Hospital and Songjiang Research Institute, Shanghai Key Laboratory of Emotions and Affective Disorders, Shanghai Jiao Tong University School of Medicine, Shanghai, China.
Article Synopsis
- The human retina has various specialized cells that work together to transmit visual signals, but genetic and age-related issues can lead to serious vision impairment or blindness.
- Current treatment options for retinal diseases are limited, highlighting the need for new therapeutic strategies, particularly cell and gene therapies that target retinal cells.
- Two main types of gene delivery systems—viral (like lentiviruses and adeno-associated viruses) and non-viral (such as liposomal technology)—are being explored for effectively delivering therapeutic genes to treat retinal diseases, each with its unique advantages and limitations.
Fe Single-Atom and Fe Cluster-Coupled N, S Co-doped Carbon Nanomaterial-Based Flexible Electrochemical Sweat Biosensor for the Real-Time Analysis of Uric Acid and Tyrosine.
ACS Sens
December 2024
Hainan International Joint Research Center of Marine Advanced Photoelectric Functional Materials, Key Laboratory of Laser Technology and Optoelectronic Functional Materials of Hainan Province, College of Chemistry and Chemical Engineering, Hainan Normal University, Haikou 571158, China.
Fe single-atom and Fe cluster-coupled N, S co-doped carbon nanomaterials (Fe-FeO-NSC) were prepared through a two-step high-temperature pyrolysis process using Gelidium corneum enriched with C, Fe, O, N, and S as precursors. The analysis by aberration-corrected scanning transmission electron microscopy and X-ray absorption spectroscopy revealed the presence of single-atom Fe in Fe-N coordination structures, along with small clusters as Fe-O-coordinated FeO. Single-atom Fe in the form of Fe/Fe provides more electrocatalytic active sites, which synergistically accelerates the charge migration process in the assembly of Fe-FeO-NSC with FeO clusters.
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