Gastrointestinal tract duplications are congenital malformations rarely seen in adulthood. Gastric duplications (GD) represent 2-9% of it. Malignant transformation of GD is a rare complication described in the literature. We present the case of a 43-year-old man, who presented an abdominal mass and an elevated CEA level. A total gastrectomy was performed and the histological examination described a gastric duplication cysts (GDC) without malignant transformation. It is not the first case of elevation of CEA in GDC without evidence of malignancy described in the literature. Some authors think that GDC are premalignant lesions that envolve with the time to carcinomas. It is recommend that once the GDC is diagnosed to remove surgically the entire cyst even if the patient is asymptomatic.
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http://dx.doi.org/10.1093/jscr/rjy114 | DOI Listing |
J Pediatr Surg
December 2024
Children's Hospital, Zhejiang University School of Medicine, National Clinical Research Center for Child Health, Hangzhou, China.
Background: Gastric duplication (GD) is a rare congenital gastrointestinal malformation, and usually identified in childhood. This study aimed to investigate the clinical characteristics and treatment of GDs in children.
Methods: A retrospective review was conducted of medical records of 38 patients with the diagnosis of GD, treated in the Department of General Surgery, Children's Hospital of Zhejiang University School of Medicine, within the period from August 2013 to December 2023.
J Biochem Mol Toxicol
January 2025
F. Zhang and H. Luo, "Diosmetin Inhibits the Growth and Invasion of Gastric Cancer by Interfering With M2 Phenotype Macrophage Polarization," Journal of Biochemical and Molecular Toxicology 37, no.
View Article and Find Full Text PDFPediatr Pulmonol
December 2024
Department of Pediatric Surgery, University of Tsukuba, Tsukuba, Japan.
Diagnostics (Basel)
December 2024
Department of Pathology, Gyeongsang National University Hospital, Jinju 52727, Republic of Korea.
Gastric duplication cysts (GDCs) are rare congenital anomalies, often identified during infancy or childhood. Although typically benign, there have been sporadic reports of malignant transformations, including adenocarcinoma and rare mixed tumors. Herein, we describe a rare case of mixed pancreatobiliary ductal adenocarcinoma and squamous cell carcinoma occurring within a GDC in a 54-year-old Korean woman with a history of melena and hematemesis.
View Article and Find Full Text PDFPeerJ
November 2024
National Research and Innovation Agency (BRIN), Research Centre for Pharmaceutical Ingredients and Traditional Medicines, Yogjakarta, Indonesia.
Objective: To critically analyse literature on the anticancer properties of andrographolide in studies on gastric cancer cells.
Method: This study systematically reviewed articles from 2013 to 2024 across five prominent databases; PubMed, Google Scholar, Web of Science, Scopus, and Science Direct, EMBASE, Cochrane library and DOAJ. The study eligibility criteria include original studies assessing using gastric cancer cell lines and articles utilizing extracted andrographolide from or standard andrographolide source treatment.
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