AI Article Synopsis
- A single rat gene can produce different mRNAs responsible for encoding either calcitonin or alpha-CGRP through alternative RNA processing.
- A related gene in rats has been found to encode a protein precursor for beta-CGRP, differing by just one amino acid from alpha-CGRP, and this appears to be the sole transcript for the beta-CGRP gene.
- Both alpha- and beta-CGRP mRNAs show similar distribution patterns in the brain, but their expression levels vary across different cranial nerve nuclei, suggesting beta-CGRP's role in sensory and motor information regulation.
Article Abstract
As a consequence of alternative RNA processing events, a single rat gene can generate messenger RNA's (mRNA's) encoding either calcitonin or a neuropeptide referred to as alpha-type calcitonin gene-related peptide (alpha-CGRP). An mRNA product of a related gene has been identified in rat brain and thyroid encoding the protein precursor of a peptide differing from alpha-CGRP by only a single amino acid. The RNA encoding this peptide, which is referred to as beta-CGRP, appears to be the only mature transcript of the beta-CGRP gene. Hybridization histochemistry reveals a similar distribution of alpha- and beta-CGRP mRNA's, but their relative levels of expression vary in different cranial nerve nuclei. Thus beta-CGRP is a new member of a family of related genes with potential functions in regulating the transduction of sensory and motor information.
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| http://dx.doi.org/10.1126/science.2994212 | DOI Listing |
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