Imaging through scattering media has been one of the main challenges in optics, and are encountered in many different disciplines of sciences, ranging from biology, mesoscopic physics to astronomy. Recently, various methods have been proposed. In this manuscript, we propose a robust method for imaging through scattering media in a reflective geometry, a scenario widely encountered in non-invasive and marker-free biological imaging. The proposed method relies on the a priori information of a known reference object in the neighborhood of the target, and uses it as an auxiliary to reconstruct the target image. We show that the target image can be analytically reconstructed from the autocorrelation of the recorded speckle if the reference is point-like, otherwise, deconvolution with the reference speckle should be performed. We experimentally demonstrate the proposed method in a proof-of-concept system with an LED illumination through a thick ground glass.
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http://dx.doi.org/10.1038/s41598-018-27754-x | DOI Listing |
ACS Sens
January 2025
The Education Ministry Key Lab of Resource Chemistry, Shanghai Key Laboratory of Rare Earth Functional Materials, Shanghai Municipal Education Committee Key Laboratory of Molecular Imaging Probes and Sensors, and Department of Chemistry, Shanghai Normal University, Shanghai 200234, P. R. China.
Microneedle (MN) sensors have great promise for food safety detection, but the rapid preparation of MNs for surface-enhanced Raman scattering (SERS) sensors with tunable and homogeneous nanoparticles remains a great challenge. To address this, a SERS sensor of gold nanoparticles@polydopamine@poly(methyl methacrylate) MN (AuNPs@PDA@PMMA-MN) was developed. The extended-Derjaguin-Landau-Verwey-Overbeek theory was applied to calculate the interaction energy between AuNPs and PDA.
View Article and Find Full Text PDFAnal Chem
January 2025
State Key Laboratory of Analytical Chemistry for Life Science, School of Chemistry and Chemical Engineering, Nanjing University, Nanjing 210023, PR China.
An entropy-driven catalysis (EDC) strategy is appealing for amplified bioimaging of microRNAs in living cells; yet, complex operation procedures, lacking of cell selectivity, and insufficient accuracy hamper its further applications. Here, we introduce an ingenious all-in-one entropy-driven DNA nanomachine (termed as AIO-EDN), which can be triggered by endogenous apurinic/apyrimidinic endonuclease 1 (APE1) to achieve tumor cell-selective dual-mode imaging of microRNA. Compared with the traditional EDC strategy, the integrated design of AIO-EDN achieves autocatalytic signal amplification without extra fuel strands.
View Article and Find Full Text PDFSci Rep
January 2025
Terahertz Research Center, School of Electronic Science and Engineering, University of Electronic Science and Technology of China, Chengdu, 610054, China.
Strong light-matter coupling occurs when the rate of energy exchange between the electromagnetic mode and the molecular ensemble exceeds the competitive dissipation process. Coupled photon molecules with near-field light-matter interactions may produce new hybridized states when they reach the strong coupling region. Tunable Terahertz (THz) meta materials can be used to design sensors, optical modulators, etc.
View Article and Find Full Text PDFInt J Nanomedicine
January 2025
College of Science, Mathematics and Technology, Wenzhou-Kean University, Wenzhou, Zhejiang, People's Republic of China.
Background: Cancer immunotherapy has achieved great success in breast cancer treatment in recent years. The Programmed Death-1 (PD-1) /Programmed Death-Ligand 1 (PD-L1) immune checkpoint pathway is among the most studied. BMS-1166, a PD-L1 inhibitor, can interfere with PD-1 and PD-L1 interaction.
View Article and Find Full Text PDFAm J Ophthalmol Case Rep
December 2024
Department of Ophthalmology, Ross Eye Institute, University at Buffalo, 1176 Main Street, Buffalo, NY, 14209, United States.
Purpose: We report a single case of ocular decompression retinopathy (ODR) following neodymium-doped yttrium aluminum garnet laser peripheral iridotomy (Nd:YAG LPI) for primary acute angle-closure glaucoma associated with delayed visual recovery secondary to optic nerve head edema and macular thickening.
Observations: A 56-year-old female patient presented to the emergency department with primary acute angle-closure glaucoma. After topical and IV therapy did not improve intraocular pressure (IOP), an Nd:YAG LPI was performed.
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