Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.1017/S1478951518000329 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
"I have never felt so alone and vulnerable" - A qualitative study of bereaved people's experiences of end-of-life cancer care during the Covid-19 pandemic.
BMC Palliat Care
December 2024
Marie Curie Research Centre, Division of Population Medicine, School of Medicine, Cardiff University, Cardiff, UK.
Background: COVID-19 drastically affected healthcare services world-wide. In the UK, many cancer services were overwhelmed as oncology staff were reassigned, and cancer diagnoses and treatments were delayed. The impact of these pressures on end-of-life care for patients with advanced cancer and their relatives is not well understood.
View Article and Find Full Text PDFAdvances of NAT10 in diseases: insights from dual properties as protein and RNA acetyltransferase.
Cell Biol Toxicol
December 2024
Department of Laboratory Medicine, Affiliated Qingyuan Hospital of Guangzhou Medical University, Qingyuan People's Hospital, Qingyuan, 511518, Guangdong, China.
N-acetyltransferase 10 (NAT10) is a member of the Gcn5-related N-acetyltransferase (GNAT) family and it plays a crucial role in various cellular processes, such as regulation of cell mitosis, post-DNA damage response, autophagy and apoptosis regulation, ribosome biogenesis, RNA modification, and other related pathways through its intrinsic protein acetyltransferase and RNA acetyltransferase activities. Moreover, NAT10 is closely associated with the pathogenesis of tumors, Hutchinson-Gilford progeria syndrome (HGPS), systemic lupus erythematosus, pulmonary fibrosis, depression and host-pathogen interactions. In recent years, mRNA acetylation has emerged as a prominent focus of research due to its pivotal role in regulating RNA stability and translation.
View Article and Find Full Text PDFDeciphering the molecular basis of lipoprotein recognition and transport by LolCDE.
Signal Transduct Target Ther
December 2024
Department of Laboratory Medicine, State Key Laboratory of Biotherapy, National Clinical Research Center for Geriatrics, West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, China.
Outer membrane (OM) lipoproteins serve vital roles in Gram-negative bacteria, contributing to their pathogenicity and drug resistance. For these lipoproteins to function, they must be transported from the inner membrane (IM), where they are assembled, to the OM by the ABC transporter LolCDE. We have previously captured structural snapshots of LolCDE in multiple states, revealing its dynamic conformational changes.
View Article and Find Full Text PDFIn Japan, the practice of advance care planning(ACP)for cancer patients may differ from Western countries due to cultural differences and the significant role of family in decision-making. Healthcare providers must consider the physical, psychological, social, and spiritual aspects of care when engaging in ACP, respecting patient autonomy and individual values. Effective communication skills and an understanding of behavioral economics are essential for navigating these discussions, particularly in the home care setting where family caregivers face unique challenges.
View Article and Find Full Text PDFIsolation and Identification of Brain Tissue Extracellular Vesicles for Translational Proteomics.
Methods Mol Biol
December 2024
Department of Biochemistry, Purdue University, West Lafayette, IN, USA.
Extracellular vesicles (EVs) are small membrane-bound structures that play important roles in intercellular communication and the transfer of biomolecules between cells. EVs have become a topic of interest for research in translational proteomics for disease biomarker discovery due to their ability to reflect changes in the cellular proteome, including diseases affecting the brain. Utilizing the proteome analysis of EVs to its fullest potential requires proper isolation and purity.
View Article and Find Full Text PDFWant AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!