AI Article Synopsis
- Amines like 1,2,3,4-tetrahydroisoquinoline react with 2-(2-oxoethyl)malonates in a redox-neutral way when catalyzed by benzoic acid.
- This reaction results in the formation of a fully saturated five-membered ring.
- The products are similar to natural compounds such as crispine A and harmicine.
Article Abstract
Amines such as 1,2,3,4-tetrahydroisoquinoline undergo redox-neutral annulations with 2-(2-oxoethyl)malonates in the presence of catalytic amounts of benzoic acid. These reactions install a fully saturated five-membered ring and provide access to structures closely related to the natural products crispine A and harmicine.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6060407 | PMC |
| http://dx.doi.org/10.1021/acs.orglett.8b01642 | DOI Listing |
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