AI Article Synopsis
- Two new furanone-containing compounds, linfuranones B and C, were discovered from a plant-associated actinomycete called Sphaerimonospora.
- Their structures were analyzed using NMR and MS techniques, with their configurations determined through various chemical methods.
- Both linfuranones B and C promoted the differentiation of preadipocytes into mature fat cells at concentrations of 20-40 μM, without causing any cell toxicity.
Article Abstract
Two new furanone-containing polyketides, linfuranones B and C, were isolated from a plant-associated actinomycete of the genus Sphaerimonospora. Their structures were determined by NMR and MS spectroscopic analyses, and the absolute configurations were established by anisotropic methods and chemical degradation approaches. In silico analysis of biosynthetic genes suggested that linfuranone B is generated from linfuranone C by oxidative cleavage of the polyketide chain. Linfuranones B and C induced preadipocyte differentiation into matured adipocytes at 20-40 μM without showing cytotoxicity.
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| http://dx.doi.org/10.1021/acs.jnatprod.8b00071 | DOI Listing |
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Linfuranones B and C, Furanone-Containing Polyketides from a Plant-Associated Sphaerimonospora mesophila.
J Nat Prod
July 2018
Biotechnology Research Center , Toyama Prefectural University, Imizu , Toyama 939-0398 , Japan.
Article Synopsis
- Two new furanone-containing compounds, linfuranones B and C, were discovered from a plant-associated actinomycete called Sphaerimonospora.
- Their structures were analyzed using NMR and MS techniques, with their configurations determined through various chemical methods.
- Both linfuranones B and C promoted the differentiation of preadipocytes into mature fat cells at concentrations of 20-40 μM, without causing any cell toxicity.
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