Background/aims: Lysyl oxidase-like 2 (LOXL2), a collagen-modifying enzyme, has been implicated in cancer invasiveness and metastasis.
Methods: We evaluated the expression of LOXL2 protein, in addition to carbonic anhydrase IX (CAIX), keratin 19, epithelial cell adhesion molecule, and interleukin 6, in 105 resected hepatocellular carcinomas (HCCs) by immunohistochemistry.
Results: LOXL2 positivity was found in 14.3% (15/105) of HCCs, and it was significantly associated with high serum α-fetoprotein levels, poor differentiation, fibrous stroma, portal vein invasion, and advanced TNM stage (p＜0.05 for all). Additionally, LOXL2 positivity was significantly associated with CAIX (p=0.005) and stromal interleukin 6 expression (p=0.001). Survival analysis of 99 HCC patients revealed LOXL2 positivity to be a poor prognostic factor; its prognostic impact appeared in progressed HCCs. Furthermore, LOXL2 positivity was shown to be an independent predictor of overall survival and disease-specific survival (p＜0.05 for all). Interestingly, co-expression of LOXL2 and CAIX was also an independent predictor for overall survival, disease-specific survival, disease-free survival, and extrahepatic recurrence-free survival (p＜0.05 for all).
Conclusions: LOXL2 expression represents a subgroup of HCCs with more aggressive behavior and is suggested to be a poor prognostic marker in HCC patients.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6347002 | PMC |
| http://dx.doi.org/10.5009/gnl17569 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Copper Dysmetabolism is Connected to Epithelial-Mesenchymal Transition: A Pilot Study in Colorectal Cancer Patients.
Biol Trace Elem Res
November 2024
Department of Biology, University of Rome Tor Vergata, Via Della Ricerca Scientifica 1, 00133, Rome, Italy.
Article Synopsis
- * Key genes related to copper metabolism, such as APP and SOD1, are found to be altered in CRC, with increased levels of APP protein in cancer tissues and changes in copper distribution between serum and tissues.
- * The study highlights a significant relationship between copper imbalance and CRC progression, suggesting that targeting copper-related proteins could be beneficial for understanding and potentially treating this cancer.
A comprehensive lifestyle index and its associations with DNA methylation and type 2 diabetes among Ghanaian adults: the rodam study.
Clin Epigenetics
October 2024
Faculty of Medicine and University Hospital, Heidelberg Institute of Global Health (HIGH), Heidelberg University, Heidelberg, Germany.
Background: A series of modifiable lifestyle factors, such as diet quality, physical activity, alcohol intake, and smoking, may drive the rising burden of type 2 diabetes (T2DM) among sub-Saharan Africans globally. It is unclear whether epigenetic changes play a mediatory role in the associations between these lifestyle factors and T2DM. We assessed the associations between a comprehensive lifestyle index, DNA methylation and T2DM among Ghanaian adults.
View Article and Find Full Text PDFSerum LOXL2 is Elevated and an Independent Biomarker in Patients with Coronary Artery Disease.
Int J Gen Med
September 2024
Department of Cardiology, Guangming Traditional Chinese Medicine Hospital of Pudong New Area, Shanghai, 201321, People's Republic of China.
Background: Arterial stiffness is associated with accelerated progression of atherosclerosis and plaque rupture. Lysyl oxidase-like 2 (LOXL2) plays a vital role in inflammatory responses, matrix deposition and arterial stiffness. This study assessed the correlation between the serum LOXL2 concentration and disease severity, inflammation, and endothelial dysfunction of coronary artery disease (CAD).
View Article and Find Full Text PDFLOXL2-induced PEAR1 Ser891 phosphorylation suppresses CD44 degradation and promotes triple-negative breast cancer metastasis.
J Clin Invest
August 2024
Department of Biochemistry and Molecular Cell Biology.
CD44 is associated with a high risk of metastasis, recurrence, and drug resistance in various cancers. Here we report that platelet endothelial aggregation receptor 1 (PEAR1) is a CD44 chaperone protein that protected CD44 from endocytosis-mediated degradation and enhances cleavage of the CD44 intracellular domain (CD44-ICD). Furthermore, we found that lysyl oxidase-like protein 2 (LOXL2), an endogenous ligand of PEAR1, bound to the PEAR1-EMI domain and facilitated the interaction between PEAR1 and CD44 by inducing PEAR1 Ser891 phosphorylation in a manner that was independent of its enzyme activity.
View Article and Find Full Text PDFProfile of key metabolites and identification of HMGCS1-DHEA pathway in porcine Sertoli cells treated by Vitamin C.
J Steroid Biochem Mol Biol
October 2024
College of Animal Science and Technology, Yangtze University, Jingzhou, Hubei 434025, China. Electronic address:
Article Synopsis
- Vitamin C is crucial for male animal reproduction, influencing the function of immature Sertoli cells in pigs by altering their transcriptome and proteome.
- A study using metabolomics revealed that vitamin C treatment significantly modifies the levels of 43 metabolites, particularly affecting steroid and protein metabolism pathways.
- Key findings indicate a strong relationship between the metabolite Dehydroepiandrosterone (DHEA) and specific genes/proteins, suggesting that HMGCS1 plays a vital role in regulating DHEA levels, which may mediate the reproductive effects of vitamin C on porcine cells.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!