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Insight into multidrug-resistant Beijing genotype Mycobacterium tuberculosis isolates in Myanmar. | LitMetric

Insight into multidrug-resistant Beijing genotype Mycobacterium tuberculosis isolates in Myanmar.

Int J Infect Dis

Hokkaido University Research Center for Zoonosis Control, Sapporo, Japan; Hokkaido University, GI-CoRE Global Station for Zoonosis Control, Sapporo, Japan. Electronic address:

Published: November 2018

AI Article Synopsis

  • Myanmar has a significant problem with multidrug-resistant tuberculosis (MDR-TB), with a high prevalence of the Beijing genotype of Mycobacterium tuberculosis (MTB) among the MDR strains.
  • A study analyzed 265 MDR-MTB isolates from 2010 and 2012 using various genetic methods, finding that 79.2% were of the Beijing genotype, predominantly the 'modern' subtype, with high clustering rates similar to strains in Russia and Central Asia.
  • The findings indicate that the spread of MDR-MTB strains of the Beijing genotype poses a serious challenge for tuberculosis control efforts in Myanmar due to genetic factors associated with extensive drug resistance.

Article Abstract

Objectives: Myanmar is a World Health Organization high tuberculosis (TB) burden country with a high multidrug-resistant (MDR)-TB burden. Of significance, a high prevalence of the Beijing genotype of Mycobacterium tuberculosis (MTB) among MDR-MTB has been reported previously. A detailed genetic characterization of TB clinical isolates was performed in order to explore whether there is an association between the prevalence of the Beijing MTB genotype and MDR-TB in Myanmar.

Methods: A total of 265 MDR-MTB clinical isolates collected in 2010 and 2012 were subjected to spoligotyping, mycobacterial interspersed repetitive unit-variable number tandem repeat (MIRU-VNTR) analysis, single nucleotide polymorphism (SNP) typing, and drug resistance-associated gene sequencing, including rpoC to detect potential compensatory evolution.

Results: Of the total MDR-MTB isolates, 79.2% (210/265) were of the Beijing genotype, the majority of which were the 'modern' subtype. Beijing genotype isolates were differentiated by 15-locus MIRU-VNTR and a high clustering rate (53.0%) was observed in the modern subtype. These MIRU-VNTR patterns were similar to Beijing genotype clones spreading across Russia and Central Asia. A high prevalence of katG Ser315Thr, and genetic evidence of extensive drug resistance (XDR) and pre-XDR and compensatory mutations in rpoC were observed among clustered isolates.

Conclusions: MDR-MTB strains of the Beijing genotype might be spreading in Myanmar and present a major challenge to TB control in this country.

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Source
http://dx.doi.org/10.1016/j.ijid.2018.06.009DOI Listing

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