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The reciprocal function and regulation of tumor vessels and immune cells offers new therapeutic opportunities in cancer. | LitMetric

The reciprocal function and regulation of tumor vessels and immune cells offers new therapeutic opportunities in cancer.

Semin Cancer Biol

VIB-Center for Cancer Biology, and KU Leuven, Department of Oncology, 3000 Leuven, Belgium; Department of Neurological Surgery, Brain Tumor Research Center, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA, 94158, USA. Electronic address:

Published: October 2018

AI Article Synopsis

Article Abstract

Tumor angiogenesis and escape of immunosurveillance are two cancer hallmarks that are tightly linked and reciprocally regulated by paracrine signaling cues of cell constituents from both compartments. Formation and remodeling of new blood vessels in tumors is abnormal and facilitates immune evasion. In turn, immune cells in the tumor, specifically in context with an acidic and hypoxic environment, can promote neovascularization. Immunotherapy has emerged as a major therapeutic modality in cancer but is often hampered by the low influx of activated cytotoxic T-cells. On the other hand, anti-angiogenic therapy has been shown to transiently normalize the tumor vasculature and enhance infiltration of T lymphocytes, providing a rationale for a combination of these two therapeutic approaches to sustain and improve therapeutic efficacy in cancer. In this review, we discuss how the tumor vasculature facilitates an immunosuppressive phenotype and vice versa how innate and adaptive immune cells regulate angiogenesis during tumor progression. We further highlight recent results of antiangiogenic immunotherapies in experimental models and the clinic to evaluate the concept that targeting both the tumor vessels and immune cells increases the effectiveness in cancer patients.

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Source
http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6548870PMC
http://dx.doi.org/10.1016/j.semcancer.2018.06.002DOI Listing

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