AI Article Synopsis
- Sinonasal undifferentiated carcinoma (SNUC) is a rare cancer with a poor prognosis, and there's limited research on effective management strategies.
- A study analyzed treatment approaches and outcomes for 54 patients, revealing 3-year overall survival and recurrence-free survival rates of 62.4% and 47.8%, respectively, with many patients experiencing metastasis or recurrence.
- Induction chemotherapy significantly improved recurrence-free survival, suggesting that multimodal treatments may enhance SNUC prognosis, although more extensive studies are needed to confirm these findings.
Article Abstract
Background: Sinonasal undifferentiated carcinoma (SNUC) is a very rare entity with a poor prognosis. Due to the lack of studies on the subject, evidence is lacking concerning its management.
Methods: A multicenter collaborative study was conducted to assess treatment strategy, oncological outcome, and prognostic factors.
Results: Definitive analyses focused on 54 patients with a majority of advanced stage; the 3-year overall survival (OS) and 3-year recurrence-free survival (RFS) rates were, respectively, 62.4% and 47.8%. During the follow-up, 18 patients (33.3%) died, 10 (18.5%) developed metastases, 7 had lymph-node involvement (13%), and 12 (22.2%) showed recurrence or local progression. In univariate analyses, treatment modalities associated with improved RFS were induction chemotherapy (p = 0.02) and intensity-modulated radiotherapy (p = 0.007). In the multivariate analyses, only induction chemotherapy (p = 0.047, hazard ratio [HR] = 0.39) was significantly associated with improved RFS.
Conclusion: Multimodal therapies including induction chemotherapy and intensity-modulated radiotherapy may improve the prognosis of SNUC; surgery might improve local control. Further multicenter studies are required.
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| http://dx.doi.org/10.1002/alr.22143 | DOI Listing |
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