AI Article Synopsis
- The study induced a type 2 diabetes rat model using a high-sugar, high-fat diet and low-dose STZ to investigate the effects of Coptis chinensis and C. deltoidea on insulin resistance and lipid levels.
- After 30 days of treatment, both C. chinensis and C. deltoidea were found to significantly reduce insulin resistance and lower levels of triglycerides (TG) by down-regulating the proteins SREBP-1c and SCAP in the liver.
- C. deltoidea was noted to be more effective at reducing lipid levels, but C. chinensis showed a stronger effect on lowering blood sugar levels in the rats.
Article Abstract
The type 2 diabetes rat model was induced with high-sugar and high-fat diet combined with low-dose STZ. This study investigated the hypolipidemic mechanism of Coptis chinensis and C. deltoidea. After 30 days of administration, HOMA-IR and the content of TG in serum were detected, and the expressions of SCAP, SREBP-1c were tested by the method of Western blot and Real-time PCR analysis. The test results showed that both components can significantly alleviate insulin resistance and down-regulate the expressions of SREBP-1c and SCAP in liver tissue of type two diabetes mellitus. Compared with the control group, there were significant differences in relevant protein expression (<0.05, <0.01). This indicates that the inhibition of SREBP-1c and SCAP expressions may be the hypolipidemic mechanism of Coptidis Rhizoma on type 2 diabetes mellitus. The results also showed that C. deltoidea has a better efficacy in lipid elimination, but a weaker hypoglycemic effect against C. chinensis.
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| http://dx.doi.org/10.19540/j.cnki.cjcmm.20180208.003 | DOI Listing |
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