Cadmium contamination of environment is a subject of serious international concern. Bioaccumulation of cadmium occurs primarily through ingestion of contaminated water and food. Cadmium poisoning came into prominence with the "itai-itai" disease event in Japan in the 1950s. It could also cause damages to liver, kidney, lung and other organs. Thus, the treatment of cadmium poisoning has become a research hotspot. Researchers are trying their best to explore prophylactic and therapeutic medicines for prevention and treatment of cadmium-induced poisoning. So far, chelation therapy, the conventional treatment for heavy metal toxicity, is reported to have a number of safety and efficacy issues. Natural medicines have a variety of advantages such as extensive sources, high safety, less adverse reactions, and thus have great potentials in treating cadmium poisoning. In this review, the progress in the antagonistic effects of natural drugs in cadmium poisoning and their therapeutic mechanisms were summarized in order to provide certain references for the future development and in-depth study of antagonistic substances.
Download full-text PDF |
Source |
|---|---|
| http://dx.doi.org/10.19540/j.cnki.cjcmm.20180125.002 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Toxicity of Polystyrene Microplastics with Cadmium on the Digestive System of Tadpoles.
Toxics
November 2024
Life and Environmental Science College, Wenzhou University, Wenzhou 325003, China.
Microplastics pollution in freshwater systems is attracting increasing attention. However, our knowledge of its combined toxicity with heavy metals is scarce. In this study, was used as the model animal to study the combined poisoning mechanism of cadmium or microplastics on the digestive systems of tadpoles in freshwater.
View Article and Find Full Text PDFHeavy metals screening model in primary care: Experience in the Sierra Minera de Cartagena (Spain).
Med Clin (Barc)
December 2024
Laboratorio Regional de Salud Pública, Consejería de Salud de la Región de Murcia, Murcia, Spain.
Introduction: Soils contaminated by heavy metals such as lead, cadmium, and arsenic represent a significant health risk. The Sierra Minera of Cartagena (Spain) is an area historically contaminated by mining activities. This study evaluates the exposure to heavy metals and proposes a clinical screening model for its management in primary care.
View Article and Find Full Text PDFCadmium exposure induces oxidative stress-mediated necroptosis via TLR4/NF-κB signaling pathway in pig epididymis.
Environ Pollut
December 2024
Branch of Animal Husbandry and Veterinary, Heilongjiang Academy of Agricultural Sciences, Qiqihar, 161005, PR China. Electronic address:
Cadmium (Cd) can cause reproductive disorders through epididymal injury. However, the specific molecular mechanism of Cd-induced epididymal toxic injury is rarely reported. In this study, the model of Cd poisoning in pig epididymis was established.
View Article and Find Full Text PDFUnveiling the Potential of Sulfur-Rich Macrocyclic Chelators Against Cadmium Poisoning.
Inorg Chem
December 2024
Department of Chemical Sciences, University of Padova, 35131 Padova, Italy.
Article Synopsis
- Cadmium is a highly toxic heavy metal that poses serious health risks, and finding effective treatments for cadmium poisoning is still a challenge despite ongoing research.* -
- This study focuses on creating better chelation therapy options by exploring sulfur-rich macrocycles with different polyamine backbones, revealing that DO4S has the strongest ability to bind and remove cadmium.* -
- The research shows that DO4S forms the most stable complex with cadmium compared to other chelators, outperforming established agents like EDTA and DTPA, indicating its potential for improved treatments for cadmium intoxication.*
Association of heavy metals and bio-elements blood level with metabolic syndrome: a systematic review and meta-analysis of observational studies.
J Diabetes Metab Disord
December 2024
Non-Communicable Diseases Research Center, Alborz University of Medical Sciences, Karaj, Iran.
Article Synopsis
- - The systematic review and meta-analysis explored the link between blood levels of heavy metals (like cadmium, mercury, lead) and essential metals (like chromium, iron, manganese, magnesium, copper) with the risk of metabolic syndrome (MetS).
- - The analysis included 29 studies, revealing that higher levels of cadmium and mercury are associated with a greater risk of MetS, while increased chromium levels correlate with a reduced risk.
- - The study concluded that certain heavy metals significantly increase the odds of developing MetS, while chromium acts protectively, highlighting the complex relationship between these metals and metabolic health.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!