With help of comprehensive methods of piezodynamic aggregometry in a microvolume and gradient ektacytometry the study was carried out to evaluate rheological properties of erythrocyte in patients with complex pathology before and after each injection of ozonated physiological solution. It was shown that after administration of physiological saline and after each session of ozone therapy occurs reduction of minimum aggregates strength and rate of spontaneous aggregation like and microviscosity and increase of deformability and water permeability of erythrocyte membranes. Dynamics of changes in the studied parameters of erythrocytes shows the improvement of the rheological properties of blood in patients not only immediately after the procedure, but and after update of blood in 2 weeks, 1 and 2 months after the course.

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