Aim: To identify potential biomarkers for the diagnosis and monitoring of HIV-1 progression.
Methods: 19 subjects, diagnosed with HIV-1 infection in the follow-up, prospective, clinical cohort more than 6000 subjects from 2006, were incorporated into our study. The subjects included ten non-progressors and nine rapid progressors. The plasmas of subjects before HIV-1 seroconversion and after seroconversion were collected and analyzed with nontargeted metabolomics.
Results: 20:0-Glc-Campesterol and A-norgorgostanol could significantly distinguished after HIV-1 seroconversion from before HIV-1 seroconversion. PG(O-18:0/18:0) could totally distinguish the plasma of rapid progressor before seroconversion from that of nonprogressor before seroconversion.
Conclusion: 20:0-Glc-Campesterol, A-norgorgostanol and PG(O-18:0/18:0) could be potential biomarkers for the diagnosis and monitoring of HIV-1 progression.
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