An efficient one-pot cascade process via unprecedented quadruple cleavage of BrCFCOOEt with primary amines to afford valuable fluorine-containing heterocycles is described, in which BrCFCOOEt plays a dual role as a C1 synthon and a difluoroalkylating reagent for the first time. Mechanistic studies supported by DFT calculations suggest that a base plays an active role in the formation of the key intermediate isocyanides generated in situ from primary amines and difluorocarbene.
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