AI Article Synopsis
- RASSF6 is a tumor suppressor that stabilizes the p53 protein by interacting with MDM2.
- The protein UNC119, an unc-119 homologue in humans, enhances the interaction between RASSF6 and MDM2, leading to increased p53 stability and triggering apoptosis.
- Depletion of UNC119 negatively affects DNA repair processes and causes polyploidy, highlighting its role as a regulator in the RASSF6-MDM2-p53 pathway and its function as a tumor suppressor.
Article Abstract
Ras-association domain family 6 (RASSF6) is a tumor suppressor that interacts with MDM2 and stabilizes p53. Caenorhabditis elegans unc-119 encodes a protein that is required for normal development of the nervous system. Humans have 2 unc-119 homologues, UNC119 and UNC119B. We have identified UNC119 as a RASSF6-interacting protein. UNC119 promotes the interaction between RASSF6 and MDM2 and stabilizes p53. Thus, UNC119 induces apoptosis by RASSF6 and p53. UNC119 depletion impairs DNA repair after DNA damage and results in polyploid cell generation. These findings support that UNC119 is a regulator of the RASSF6-MDM2-p53 axis and functions as a tumor suppressor.
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Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6125449 | PMC |
| http://dx.doi.org/10.1111/cas.13706 | DOI Listing |
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