Border collies of the genome: domestication of an autonomous retrovirus-like transposon.

Curr Genet

Laboratory of Molecular Genetics, Wadsworth Center, Albany, NY, USA.

Published: February 2019

AI Article Synopsis

  • Retrotransposons can quickly proliferate in eukaryotic genomes but are eventually controlled by the host's defense mechanisms and may become non-harmful.
  • The Ty1 retrotransposon is an example of this process, as it has been adapted by the yeast Saccharomyces cerevisiae.
  • This domestication allows the Ty1 retrotransposon to help protect the yeast's genome rather than pose a threat.

Article Abstract

Retrotransposons often spread rapidly through eukaryotic genomes until they are neutralized by host-mediated silencing mechanisms, reduced by recombination and mutation, and lost or transformed into benevolent entities. But the Ty1 retrotransposon appears to have been domesticated to guard the genome of Saccharomyces cerevisiae.

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http://dx.doi.org/10.1007/s00294-018-0857-1DOI Listing

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