AI Article Synopsis
- Angiolymphoid Hyperplasia with eosinophilia (ALHE) is a rare, benign vascular lesion mainly affecting the skin and subcutaneous tissues, particularly in the head and neck, but it is rarely found in the oral cavity.
- The cause of ALHE is not well understood and it may be classified as a reactive vascular proliferation, vascular malformation, or neoplasm, with Kimura's disease being a key condition in the differential diagnosis.
- A case study reported a 50-year-old male with a nodular swelling on the upper lip that persisted for 7 years, which upon excisional biopsy, revealed a well-encapsulated, multi-lobed lesion consisting of blood capillaries, lymphocytes,
Article Abstract
Angiolymphoid Hyperplasia with eosinophilia (ALHE) is considered a rare, benign vascular lesion that mainly affects the skin and subcutaneous tissues of the head and neck, but is uncommon in the oral cavity. Its etiology remains unclear and it has been described as a reactive vascular proliferation, vascular malformation or neoplasm. Kimura's disease is the primary entity to consider in differential diagnosis. Here we report on a rare case of ALHE involving the upper lip of a 50-year-old male patient that had a nodular swelling with approximately 3 cm, 7 years after initial onset. An excisional biopsy was performed and histopathologic examination revealed a well-encapsulated, multi-lobed lesion with proliferation of blood capillaries, displaying endothelial cells of epithelioid appearance, diffuse inflammatory infiltrate with lymphocytes, plasma cells, numerous eosinophils, and presence of lymphoid follicles. Immunohistochemical tests were positive for the markers CD34 and Ki-67 that, in combination with the results of morphological examination, were suggestive of a diagnosis of ALHE.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC5829732 | PMC |
| http://dx.doi.org/10.1590/1677-5449.004516 | DOI Listing |
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