Previous epidemiologic studies have revealed a possible association between microRNA-608 rs4919510 G>C polymorphism and digestive system cancers (DSCs) risk, but the results were not consistent. We therefore performed an updated meta-analysis to explore the association between microRNA-608 rs4919510 G>C polymorphism and DSCs risk. Crude odds ratios (ORs) with 95% confidence intervals (CIs) were calculated to assess the relationship between the microRNA-608 rs4919510 G>C polymorphism and DSCs risk. Heterogeneity, cumulative analyses, sensitivity analyses, and publication bias were also conducted to examine the statistical power. Eight published articles with nine independent case-control studies involving 10,836 individuals were included in this meta-analysis. Overall, no significant association was found between microRNA-608 rs4919510 G>C polymorphism and DSCs risk in general populations. But some significant protective effects were observed in the subgroup of Caucasian population group in three genetic models (C vs. G: OR = 0.82, 95% CI, 0.68-0.99, = 0.03, = 0%; CC vs. GG: OR = 0.59, 95% CI = 0.36-0.97, = 0.04, = 0%; GC+CC vs. GG: OR = 0.61, 95% CI = 0.37-0.99, = 0.05, = 0%). In summary, current evidence indicates that the microRNA-608 rs4919510 G>C polymorphism maybe an important factor of DSCs susceptibility, especially in Caucasian population.
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| http://dx.doi.org/10.3389/fphys.2018.00705 | DOI Listing |
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School of Basic Medical Sciences, Qingdao University, Qingdao, China.
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Front Physiol
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Article Synopsis
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- * The rs4919510 GG genotype was linked to poorer recurrence-free survival among cancer patients, indicating the need for further research on larger populations to confirm these findings.
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Department of Medicine, The Royal Marsden NHS Foundation Trust, Surrey SM2 5PT, UK, Department of Molecular Pathology, The Institute of Cancer Research, Surrey SM2 5NG, UK,
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