AI Article Synopsis
- The autophagosome is a specialized structure that helps in degrading and recycling cellular components during the process of autophagy.
- Advances in research have shown that the endoplasmic reticulum (ER) plays a crucial role in the formation of autophagosomes, acting as both a source of membranes and a regulator of autophagy.
- This overview compares the process of autophagosome formation in plants with the latest findings in yeast and mammals, focusing on key proteins involved and the trafficking of ATG proteins.
Article Abstract
The autophagosome is a double-membrane compartment formed during autophagy that sequesters and delivers cargoes for their degradation or recycling into the vacuole. Analyses of the AuTophaGy-related (ATG) proteins have unveiled dynamic mechanisms for autophagosome biogenesis. Recent advances in plant autophagy research highlight a complex interplay between autophagosome biogenesis and the endoplasmic reticulum (ER): on the one hand ER serves as a membrane source for autophagosome initiation and a signaling platform for autophagy regulation; on the other hand ER turnover is connected to selective autophagy. We provide here an integrated view of ER-based autophagosome biogenesis in plants in comparison with the newest findings in yeast and mammals, with an emphasis on the hierarchy of the core ATG proteins, ATG9 trafficking, and ER-resident regulators in autophagy.
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| http://dx.doi.org/10.1016/j.tplants.2018.05.002 | DOI Listing |
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