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http://dx.doi.org/10.1016/j.hrcr.2018.02.014DOI Listing

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Article Synopsis
  • * A case study of four VSA patients revealed that all experienced significant coronary vasoconstriction during acetylcholine testing, but their ECGs differed between spontaneous episodes and induced spasms in three out of four cases.
  • * The findings indicate that the ECG during spontaneous VSA episodes may not match those seen during acetylcholine-induced spasms, emphasizing the need for ECG monitoring during spontaneous angina to improve diagnosis
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Epicardial atherosclerosis and coronary tortuosity in patients with acetylcholine-induced coronary spasm.

Coron Artery Dis

January 2023

Department of Cardiology and Angiology, Robert-Bosch-Krankenhaus, Stuttgart, Germany.

Background: Angina pectoris in the absence of relevant epicardial stenoses is frequently caused by coronary spasm. This mechanism of angina is common yet underdiagnosed in daily clinical practice. The pathophysiology of coronary spasm is complex, multifactorial, and not completely understood.

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Coronary spasm is an established cause for angina pectoris. Ethnic differences have been suggested among Asian compared to Caucasian patients regarding prevalence, gender distribution, and angiographic patterns of coronary spasm. The aim of this study was to compare contemporary German and Japanese patients with coronary spasm.

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Slow coronary flow is frequently seen during angiography in patients with angina and unobstructed coronary arteries. However, the pathophysiology of this finding remains largely unclear. We report a case of a 52-year-old woman with slow coronary flow caused by acetylcholine-induced microvascular spasm, as confirmed by intracoronary flow measurements.

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Strong Relationship Between Vascular Function in the Coronary and Brachial Arteries.

Hypertension

July 2019

From the Department of Internal Medicine (R.M.B., J.D.T., S.M., C.L.J., T.O., A.A., A.T., C.Y.L., B.R.S., R.S.R.), University of Utah, Salt Lake City.

Early detection of coronary artery dysfunction is of paramount cardiovascular clinical importance, but a noninvasive assessment is lacking. Indeed, the brachial artery flow-mediated dilation test only weakly correlated with acetylcholine-induced coronary artery function ( r=0.36).

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