AI Article Synopsis
- In light of the opioid crisis, there's increasing interest in ketamine as a pain relief option.
- Ketamine works on various receptors in the brain, affecting pain relief and mood through its interactions with NMDA, opioid receptors, and others.
- This review looks at the basic workings of ketamine and its current and potential future roles in managing both acute and chronic pain.
Article Abstract
Objective: In the context of the current opioid epidemic, there has been a renewed interest in the use of ketamine as an analgesic agent.
Methods: We reviewed ketamine analgesia.
Results: Ketamine is well-known as an antagonist for N-methyl-D-aspartate receptors. In addition, it can regulate the function of opioid receptors and sodium channels. Ketamine also increases signaling through α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid receptors. These myriad of molecular and cellular mechanisms are responsible for a number of pharmacological functions including pain relief and mood regulation. Clinically, a number of studies have investigated the role of ketamine in the setting of acute and chronic pain, and there is evidence that ketamine can provide analgesia in a variety of pain syndromes.
Discussion: In this review, we examined basic mechanisms of ketamine and its current clinical use and potential novel use in pain management.
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| http://dx.doi.org/10.1097/AJP.0000000000000635 | DOI Listing |
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