AI Article Synopsis
- Citrofulvicin, an antiosteoporotic compound derived from the fungus Penicillium velutinum, has a unique chemical structure previously unrecognized in skeletal research.
- This compound, along with its precursor fulvionol, is believed to form through a special nonenzymatic reaction involving heptaketide intermediates.
- Both citrofulvicin and fulvionol showed osteogenic properties at a low concentration (0.1 μM) in a zebrafish model induced with osteoporosis by prednisolone.
Article Abstract
Citrofulvicin (1), along with its early shunt product fulvionol (2), was characterized as a skeletally unprecedented antiosteoporotic agent from a human sputum-derived fungus Penicillium velutinum. The unique citrofulvicin framework is likely formed by a nonenzymatic intermolecular Diels-Alder cycloaddition between heptaketide-based intermediates. Citrofulvicin and fulvionol were demonstrated to be osteogenic at 0.1 μM in the prednisolone-induced osteoporotic zebrafish.
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| http://dx.doi.org/10.1021/acs.orglett.8b01272 | DOI Listing |
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