AI Article Synopsis
- - A 58-year-old woman was diagnosed with IgG4-related disease in her upper eyelids, characterized by swelling and ulceration, confirmed by biopsy showing increased IgG4-positive plasma cells
- - The patient's serum IgG4 levels were elevated and specialized imaging revealed significant activity localized to her eyelids
- - Treatment with oral and topical steroids resulted in substantial improvement of the eyelid lesions, indicating effective management of this specific condition
Article Abstract
Purpose: To describe a clinical case of bilateral biopsy-proven IgG4-related disease confined to the tarsal plate.
Method: Interventional case report.
Results: A 58-year-old woman presented with a tarsal swelling in the lateral part of the upper eyelids, with focal ulceration and mucus. Histology revealed fibrotic inflammation with increased IgG4-positive plasma cells fulfilling the criteria of IgG4-related disease (IgG4-RD). Serum IgG4 levels were increased, and pathological fluorodeoxyglucose uptake at positron emission tomography/CT scanning was restricted to the upper eyelids. After treatment with oral and topical prednisone, the tarsal lesions markedly regressed.
Conclusions: Periorbital IgG4-RD may be confined to the tarsal plate. Treatment with systemic and topical steroids may induce significant regression.
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| http://dx.doi.org/10.1007/s10792-018-0974-3 | DOI Listing |
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