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The adult mouse olfactory bulb is continuously supplied with new neurons that mostly differentiate into granule cells (GCs). Different subtypes of adult-born GCs have been identified, but their maturational profiles and their roles in bulbar network functioning and odor behavior remain elusive. It is also not known whether the same subpopulations of GCs born during early postnatal life (early-born) or during adulthood (adult-born) differ in their morpho-functional properties. Here, we show that adult-born calretinin-expressing (CR) and non-expressing (CR) GCs, as well as early-born CR GCs, display distinct inhibitory inputs but indistinguishable excitatory inputs and similar morphological characteristics. The frequencies of inhibitory post-synaptic currents were lower in early-born and adult-born CR GCs than in adult-born CR neurons. These findings were corroborated by the reduced density of gephyrin puncta on CR GCs. CR GCs displayed a higher level of activation following olfactory tasks based on odor discrimination, as determined by an immediate early gene expression analysis. Pharmacogenetic inhibition of CR GCs diminished the ability of the mice to discriminate complex odor mixtures. Altogether, our results indicate that distinct inhibitory inputs are received by adult-born CR and CR GCs, that early- and adult-born CR neurons have similar morpho-functional properties, and that CR GCs are involved in complex odor discrimination tasks.
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http://dx.doi.org/10.1038/s41598-018-27692-8 | DOI Listing |
Cogn Neurodyn
October 2024
Institute for Computational Neuroscience and Department of Science Education, Daegu National University of Education, Daegu, 42411 Korea.
Unlabelled: We are concerned about sparsely synchronized rhythms (SSRs), associated with diverse cognitive functions, in the hippocampal dentate gyrus. Distinctly, adult-born immature GCs (imGCs) emerge through neurogenesis, in addition to the mature granule cells (mGCs) (emerged in the developmental stage). In prior work, these mGCs and imGCs were found to exhibit their distinct roles in pattern separation and integration for encoding cortical inputs, respectively.
View Article and Find Full Text PDFNeural activity in the dentate gyrus (DG) is required for the detection and discrimination of novelty, context and patterns, amongst other cognitive processes. Prior work has demonstrated that there are differences in the activation of granule neurons in the supra and infrapyramidal blades of the DG during a range of hippocampal dependent tasks. Here we used an automated touch screen pattern separation task combined to temporally controlled tagging of active neurons to determine how performance in a cognitively demanding task affected patterns of neural activity in the DG.
View Article and Find Full Text PDFCogn Neurodyn
August 2024
Institute for Computational Neuroscience and Department of Science Education, Daegu National University of Education, Daegu, 42411 Korea.
Young immature granule cells (imGCs) appear via adult neurogenesis in the hippocampal dentate gyrus (DG). In comparison to mature GCs (mGCs) (born during development), the imGCs exhibit two competing distinct properties such as high excitability (increasing activation degree) and low excitatory innervation (reducing activation degree). We develop a spiking neural network for the DG, incorporating both the mGCs and the imGCs.
View Article and Find Full Text PDFNeural Dev
June 2024
Neuroscience Department, Wellesley College, Wellesley, MA, 02481, USA.
Adult neurogenesis, which takes place in both vertebrate and invertebrate species, is the process by which new neurons are born and integrated into existing functional neural circuits, long after embryonic development. Most studies in mammals suggest that self-renewing stem cells are the source of the new neurons, although the extent of self-renewal is a matter of debate. In contrast, research in the crayfish Procambarus clarkii has demonstrated that the neural progenitors producing adult-born neurons are capable of both self-renewing and consuming (non-self-renewing) divisions.
View Article and Find Full Text PDFJ Neurosci
April 2024
Department of Neurobiology and McKnight Brain Institute, University of Alabama at Birmingham, Birmingham, Alabama 35294
Adult-born granule cells (abGCs) exhibit a transient period of elevated synaptic plasticity that plays an important role in hippocampal function. Various mechanisms have been implicated in this critical period for enhanced plasticity, including minimal GABAergic inhibition and high intrinsic excitability conferred by T-type Ca channels. Here we assess the contribution of synaptic inhibition and intrinsic excitability to long-term potentiation (LTP) in abGCs of adult male and female mice using perforated patch recordings.
View Article and Find Full Text PDFEnter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!