Here we report the case of a 78-year-old male patient with a 2-day history of low visual acuity and fundus and who was diagnosed with central retinal artery occlusion. In addition, the patient had an allergy to fluorescein. A fundus examination of the left eye found a pink optic disc with blurred margins, diffuse pallor in the retina with arterial attenuation, and a normal band of the retinal area in the macular region. Optical coherence tomography revealed increased thickness of the inner retina. Optical coherence tomography angiography (OCT-A) revealed a decreased flow signal in the superficial layers, with reduced flow signal in the choriocapillaris. OCT-A is a valuable alternative during the follow-up period in patients with central retinal artery occlusion, particularly in those with an allergy to contrast agents. The use of this as a non-invasive examination can improve the prognosis of patients and future studies investigating the treatment of central retinal artery occlusion.
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http://dx.doi.org/10.5935/0004-2749.20180048 | DOI Listing |
Retinopathy of prematurity (ROP) and diabetic retinopathy (DR) are ocular disorders in which a loss of retinal vasculature leads to ischemia followed by a compensatory neovascularization response. In mice, this is modeled using oxygen-induced retinopathy (OIR), whereby neonatal animals are transiently housed under hyperoxic conditions that result in central retina vessel regression and subsequent neovascularization. Using endothelial cell (EC)-specific gene deletion, we found that loss of two ETS-family transcription factors, ERG and FLI1, led to regression of OIR-induced neovascular vessels but failed to improve visual function, suggesting that relevant retinal damage occurs prior to and independently of neovascularization.
View Article and Find Full Text PDFObjective: To investigate the long-term impact of half-fluence photodynamic therapy (PDT) on chorioretinal architecture in chronic central serous chorioretinopathy (cCSCR) through novel choroidal vascularity index (CVI) versus previously established subfoveal choroidal thickness (SFCT).
Methods: This post-hoc analysis included prospectively collected swept-source optical coherence tomography (SS-OCT) images of a total of 29 cCSCR and fellow eyes (FE), acquired before, one and 12 months after PDT. CVI, total choroidal area (TCA), luminal area (LA) and stromal area (SA) were calculated using validated binarization technique.
Sci Rep
January 2025
Faculty of Electronic Information and Physics, Central South University of Forestry and Technology, Changsha, 410004, Hunan, China.
Accurate segmentation of retinal blood vessels from retinal images is crucial for detecting and diagnosing a wide range of ophthalmic diseases. Our retinal blood vessel segmentation algorithm enhances microfine vessel extraction, improves edge texture clarity, and normalizes vessel distribution. It stabilizes neural network training for complex retinal vascular features.
View Article and Find Full Text PDFSci Rep
January 2025
Department of Ophthalmology, Kim's Eye Hospital, #156 Youngdeungpo-dong 4ga, Youngdeungpo-gu, 150-034, Seoul, South Korea.
To evaluate the outcomes and predictive factors for fluid resolution following three loading injections of faricimab for neovascular age-related macular degeneration(AMD). This retrospective study included patients diagnosed with treatment-naïve neovascular AMD who received three monthly injections of faricimab. Changes in best-corrected visual acuity(BCVA) and central retinal thickness(CRT) following treatment were evaluated.
View Article and Find Full Text PDFRetin Cases Brief Rep
January 2025
Manchester Manchester Royal Eye Hospital, Manchester University Hospitals NHS Foundation Trust, Manchester, UK.
Purpose: To describe a case of central retinal artery occlusion following scleral buckling procedure combined with pneumoretinopexy in a patient with sickle cell (HbSC) retinopathy (SCR).
Methods: Scleral buckling procedure, combined with injection of 0.3 ml of 100% perfluoropropane (C3F8) gas in the vitreous, was performed without intra-operative complications under general anaesthesia as treatment of two separate macula-sparing rhegmatogenous retinal detachments secondary to round holes, involving superior and inferior retina respectively, in the right eye of a 26-year-old Afro-Caribbean female with sickle cell disease.
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