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Food intake and the HPT axis in the cichlid fish: The implications of the gut-brain peptide cholecystokinin.
Comp Biochem Physiol A Mol Integr Physiol
January 2025
Neuroendocrinology Research Laboratory, Department of Studies in Zoology, Karnatak University, Dharwad 580 003, India. Electronic address:
This work aimed to investigate the response of cholecystokinin (CCK) to starvation and its impact on food intake and the reproductive axis of the tilapia Oreochromis mossambicus. The fish subjected to 21 days of starvation showed a significant decrease in CCK immunoreactivity in the hypothalamus, pituitary gland, and intestine. The administration of injections of 0.
View Article and Find Full Text PDFMethod for measuring cervical vagal nerve activity in conscious rats.
Am J Physiol Endocrinol Metab
January 2025
Autonomic Physiology Laboratory, Faculty of Life Science and Human Technology, Nara Women's University, Kita-Uoya Nishimachi, Nara, 630-8506, Japan.
The current study aimed to propose a method to directly measure right cervical vagal nerve activity (cVNA) alongside renal sympathetic nerve activity (RSNA) in conscious rats. The right cervical vagus nerve was surgically exposed and fitted with a bipolar electrode to record cVNA. A microcatheter was used to administer levobupivacaine to selectively block afferent cVNA.
View Article and Find Full Text PDFComparison of Two Chelator Scaffolds as Basis for Cholecystokinin-2 Receptor Targeting Bimodal Imaging Probes.
Pharmaceuticals (Basel)
November 2024
Department of Nuclear Medicine, Medical University of Innsbruck, 6020 Innsbruck, Austria.
: Dual-modality probes, combining positron emission tomography (PET) with fluorescence imaging (FI) capabilities in a single molecule, are of high relevance for the accurate staging and guided resection of tumours. We herein present a pair of candidates targeting the cholecystokinin-2 receptor (CCK2R), namely [Ga]Ga-CyTMG and [Ga]Ga-CyFMG. In these probes, the SulfoCy5.
View Article and Find Full Text PDFKidney Gastrin/CCKBR Attenuates Type 2 Diabetes Mellitus by Inhibiting SGLT2-Mediated Glucose Reabsorption through Erk/NF-κB Signaling Pathway.
Diabetes Metab J
December 2024
Institute of Laboratory Animal Science, Chinese Academy of Medical Sciences (CAMS) & Comparative Medicine Center, Peking Union Medical College (PUMC), and Beijing Engineering Research Center for Experimental Animal Models of Human Critical Diseases, Beijing, China.
Background: Both sodium-glucose cotransporters (SGLTs) and Na+/H+ exchangers (NHEs) rely on a favorable Na-electrochemical gradient. Gastrin, through the cholecystokinin B receptor (CCKBR), can induce natriuresis and diuresis by inhibiting renal NHEs activity. The present study aims to unveil the role of renal CCKBR in diabetes through SGLT2-mediated glucose reabsorption.
View Article and Find Full Text PDFEffect of synbiotic supplementation on obesity and gut microbiota in obese adults: a double-blind randomized controlled trial.
Front Nutr
November 2024
Key Laboratory of Functional Dairy, Co-Constructed by Ministry of Education and Beijing Government, Department of Nutrition and Health, China Agricultural University, Beijing, China.
Article Synopsis
- This study investigated the effects of a specific combination of synbiotics—probiotics and prebiotics—on obesity among 80 individuals over 12 weeks.
- Participants were randomly assigned to consume either synbiotics or a placebo, with various health metrics monitored before and after the intervention.
- Results showed that synbiotics significantly reduced body fat, waist size, and harmful cholesterol levels while promoting beneficial gut bacteria and hormone changes, particularly benefiting those with abnormal cholesterol levels.
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