AI Article Synopsis
- The text discusses a Gram-negative bacterium responsible for Q fever, a zoonotic disease that affects various hosts, including humans and animals.
- It highlights the challenges of studying the bacterium's virulence in costly and ethically constrained mammalian models.
- The study presents an alternative approach using a specific larval model to investigate the virulence of strains isolated from domesticated ruminants.
Article Abstract
is a small Gram-negative intracellular bacterium and is the causative agent of Q fever, which is a zoonotic disease with a worldwide distribution. Domesticated ruminants are the main reservoir of the disease, but the bacterium is able to infect a wide range of hosts, including humans, arthropods and invertebrates. Virulence studies of strains usually require a suitable animal model. However, mammalian models are costly and are associated with many ethical constraints. An alternative infection model using has been used to study the virulence of several bacterial as well as fungal pathogens. Moreover, the larvae model has been used to identify virulence genes using phase II strain Nine Mile mutants. In our study we describe its use for the characterization of strains isolated from ruminants.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6004733 | PMC |
| http://dx.doi.org/10.1016/j.nmni.2018.02.008 | DOI Listing |
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