Objective: To appraise and synthesise research on the impact of physician assistants/associates (PA) in secondary care, specifically acute internal medicine, care of the elderly, emergency medicine, trauma and orthopaedics, and mental health.
Design: Systematic review.
Setting: Electronic databases (Medline, Embase, ASSIA, CINAHL, SCOPUS, PsycINFO, Social Policy and Practice, EconLit and Cochrane), reference lists and related articles.
Included Articles: Peer-reviewed articles of any study design, published in English, 1995-2017.
Interventions: Blinded parallel processes were used to screen abstracts and full text, data extractions and quality assessments against published guidelines. A narrative synthesis was undertaken.
Outcome Measures: Impact on: patients' experiences and outcomes, service organisation, working practices, other professional groups and costs.
Results: 5472 references were identified and 161 read in full; 16 were included-emergency medicine (7), trauma and orthopaedics (6), acute internal medicine (2), mental health (1) and care of the elderly (0). All studies were observational, with variable methodological quality. In emergency medicine and in trauma and orthopaedics, when PAs are added to teams, reduced waiting and process times, lower charges, equivalent readmission rate and good acceptability to staff and patients are reported. Analgesia prescribing, operative complications and mortality outcomes were variable. In internal medicine outcomes of care provided by PAs and doctors were equivalent.
Conclusions: PAs have been deployed to increase the capacity of a team, enabling gains in waiting time, throughput, continuity and medical cover. When PAs were compared with medical staff, reassuringly there was little or no negative effect on health outcomes or cost. The difficulty of attributing cause and effect in complex systems where work is organised in teams is highlighted. Further rigorous evaluation is required to address the complexity of the PA role, reporting on more than one setting, and including comparison between PAs and roles for which they are substituting.
Prospero Registration Number: CRD42016032895.
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http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6020983 | PMC |
http://dx.doi.org/10.1136/bmjopen-2017-019573 | DOI Listing |
Am J Geriatr Psychiatry
February 2025
Department of Psychiatry (AJCS, EJG), Leiden University Medical Center, Leiden, The Netherlands; Health Campus The Hague (EJG), Department of Public Health & Primary Care, Leiden University Medical Center, Leiden, The Netherlands. Electronic address:
Background: The prevalence of depressive symptoms, apathy, and cognitive decline increases with age. Understanding the temporal dynamics of these symptoms could provide valuable insights into the early stages of cognitive decline, allowing for more timely and effective treatment and management.
Methods: Participants from the Prevention of Dementia by Intensive Vascular Care (preDIVA) trial cohort with baseline and ≥3 follow-up measurements were included, with a median of 7.
Eur Urol
March 2025
Division of Medical Oncology, Department of Internal Medicine, Huntsman Cancer Institute, University of Utah, Salt Lake City, UT, USA. Electronic address:
Owing to the "cold" tumor immune microenvironment of prostate cancer, immune-targeting agents have shown limited efficacy in patients with advanced prostate cancer, highlighting the need for new therapies with novel mechanisms of action. In this context, T-cell engagers (TCEs), which induce T-cell-mediated killing of cancer cells by binding the CD3 receptor on T cells and a specific tumor antigen expressed on malignant cells, represent a promising therapeutic option. Multiple studies have explored the use of TCEs in previously treated patients with metastatic castration-resistant prostate cancer, and several ongoing trials are currently assessing novel TCEs either as single agents or in combinatorial regimens with molecules with a distinct mechanism of action (eg, androgen receptor pathway inhibitors and other immune-targeting agents).
View Article and Find Full Text PDFJ Microbiol Immunol Infect
March 2025
Division of Pediatric Infectious Diseases, Chang Gung Memorial Hospital at Linkou, Taoyuan, Taiwan; Chang Gung University School of Medicine, Taoyuan, Taiwan. Electronic address:
Background: Strict mask wearing and handwashing were implemented in hospital settings during COVID-19 pandemic in Taiwan. To explore if nasal methicillin-resistant Staphylococcus aureus (MRSA) carriage rate among inpatients in the hospital changed before and after COVID-19, we conducted this study.
Methods: Patients who were admitted to a regional hospital in central Taiwan during one week in 2012 and 2023, respectively, were enrolled.
J Microbiol Immunol Infect
March 2025
Division of Infection, Department of Internal Medicine, Ministry of Health and Welfare Shuang-Ho Hospital, New Taipei City, Taiwan; Department of Internal Medicine, School of Medicine, College of Medicine, Taipei Medical University, Taipei, Taiwan. Electronic address:
J Clin Lipidol
February 2025
Fatty Acid Research Institute, Sioux Falls, SD, USA (Drs Tintle, Marchioli, and Harris); Department of Internal Medicine, Sanford School of Medicine, University of South Dakota, Sioux Falls, SD, USA (Dr Harris).
Background: Accurate predictive tools are crucial for identifying patients at increased risk for atherosclerotic cardiovascular disease (ASCVD). The Pooled Cohort Equation (PCE) is commonly used to predict 10-year risk for ASCVD, but its accuracy remains imperfect.
Objective: This study examined the extent to which the omega-3 index (O3I; the proportion of eicosapentaenoic acid+docosahexaenoic acid in erythrocyte membranes) improved the predictive capability of PCE.
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