Transgenic Artifacts Caused by Passenger Human Growth Hormone.

Trends Endocrinol Metab

Laboratory for Biochemical Neuroendocrinology, Department of Human Genetics, KU Leuven, Leuven, Belgium; Institute of Biomedical Research in Malaga (IBIMA), Virgen de la Victoria University Hospital, Malaga, Spain; Centro de Investigación Biomédica en Red (CIBER) Physiopathology of Obesity and Nutrition (CIBEROBN), Institute of Health Carlos III, Madrid, Spain.

Published: October 2018

The minigene encoding human growth hormone (hGH) has been incorporated into over 300 transgenic mouse lines to improve transgene expression. However, unexpected and functional hGH expression can drastically alter physiology. We list here the mouse lines in which ectopic hGH has been confirmed, and we provide a wiki for lines awaiting analysis.

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http://dx.doi.org/10.1016/j.tem.2018.05.005DOI Listing

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