Purpose: Recently, the diastolic strain rate (DSR) utilizing speckle-tracking echocardiography has been proposed as a novel parameter for left ventricular diastolic function. We aimed to present normal reference data for those in a large-sized, selected group of healthy individuals.
Methods: The current study was a part of the Normal echOcardiogRaphic Measurements in KoreAn popuLation (NORMAL), a prospective nationwide survey from 23 centers in Korea. We analyzed 447 subjects (age 48 ± 15 years, 234 females) without any history of cardiovascular disease and presented the early and late DSRs (SR and SR , respectively) in a total and gender-/age-specified groups.
Results: Among the total subjects, the mean SR and SR were 1.6 ± 0.4 S and 0.8 ± 0.3 S , respectively. With increasing age, there were significant trends of decreasing SR and increasing SR . Although both gender groups showed comparable age, the female group presented significantly higher SR compared to male subjects with age of 20-59 years, which diminished after the age of 60 years. However, the SR was comparable between genders in all age groups. On multiple linear regression, age showed independent associations with both SR (β = -0.132, P = .010) and SR (β = 0.440, P < .001), whereas gender did not show any association with SR or SR .
Conclusion: We present normal reference data of a novel parameter, DSR, in a large-sized selected group with healthy Korean subjects. Additionally, we present significant age-related changes both in SR and SR without the impact of their gender.
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