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Insights in biomarkers complexity and routine clinical practice for the diagnosis of thyroid nodules and cancer.
PeerJ
January 2025
Instituto de Patologia e Imunologia Molecular da Universidade do Porto (IPATIMUP), i3S-Institute for Research & Innovation in Health, Porto, Portugal.
Background: The differential diagnosis between benign and malignant thyroid nodules continues to be a major challenge in clinical practice. The rising incidence of thyroid neoplasm and the low incidence of aggressive thyroid carcinoma, urges the exploration of strategies to improve the diagnostic accuracy in a pre-surgical phase, particularly for indeterminate nodules, and to prevent unnecessary surgeries. Only in 2022, the 5th WHO Classification of Endocrine and Neuroendocrine Tumors, and in 2023, the 3rd Bethesda System for Reporting Thyroid Cytopathology and the European Thyroid Association included biomarkers in their guidelines.
View Article and Find Full Text PDFGenetic determinants of COVID-19 severity and mortality: Alu 287 bp polymorphism and , , expression in hospitalized patients.
PeerJ
January 2025
Departamento de genética, ecologia e evolução, Laboratório de biologia integrativa, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil.
Background: The angiotensin-converting enzyme 2 (ACE2) and the transmembrane serine protease 2 (TMPRSS2) are central human molecules in the SARS-CoV-2 virus-host interaction. Evidence indicates that may influence expression. This study aims to determine whether ACE1, ACE2, and TMPRSS2 mRNA expression levels, along with the ACE1 Alu 287 bp polymorphism (rs4646994), contribute to the severity and mortality of COVID-19.
View Article and Find Full Text PDFA comparative evaluation of haematological and biochemical parameters of and species living in Gökova Bay, Türkiye.
PeerJ
January 2025
Faculty of Fisheries, Muğla Sıtkı Koçman University, Muğla, Türkiye.
This study aims to determine and compare the reference values of the haematological and biochemical blood parameters of two fish species collected from the Gökova Bay (Muğla, South-Western of Türkiye): the non-native and invasive Randall's threadfin bream, and the native Common pandora, . Both species inhabit the same environment and compete for resources. Blood samples were collected from a total of 100 fish samples (50 and 50 ) which were caught from a depth of 30 to 60 meters between February 2023 and July 2024.
View Article and Find Full Text PDFLetter to the Editor in response to Performance of the Washington Group questions in measuring blindness and deafness by Landes et al.
Health Aff Sch
January 2025
Burton Blatt Institute, Syracuse University, Syracuse, NY 13244-2130, United States.
A Farewell Note with Parting Reflections.
Indian Dermatol Online J
December 2024
Editor-in-Chief (2022-2024) Indian Dermatology Online Journal (IDOJ).
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