The authors of this article integrate two historically parallel yet disparate fields of nursing, caring science theory and nursing quantum leadership science. Through a nursing, discipline-specific unitary paradigm lens, intersecting principles of caring science and quantum leadership science are uncovered. The result is a model for unitary, discipline-specific, nursing healthcare leadership: Quantum Caring Healthcare Leadership. Ontological congruence is uncovered among the philosophical-ethical-theoretical principles of caring science and the unifying disciplinary structural concepts from quantum leadership. The result is a model for discipline-specific, healthcare leadership. This convergence is potentially theory-generating for both unitary science and healthcare leadership. In this model, both quantum leadership and caring science are transformed and metamorphosed into a new unitary, discipline-specific entity to guide further advancement of knowledge, theory, and discipline-specific healthcare leadership and practice.
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http://dx.doi.org/10.1177/0894318418774893 | DOI Listing |
Breast Cancer Res Treat
December 2024
University of California San Francisco, Box 1710, San Francisco, CA, 94143, USA.
Purpose: We investigated the small-molecule receptor tyrosine kinase-inhibitor of colony-stimulating factor-1 receptor pexidartinib in the stage II/III breast cancer in the I-SPY2 platform trial.
Methods: I-SPY2 is an adaptive platform trial that features multiple arms of experimental agents administered on a background of standard neoadjuvant therapy with paclitaxel and adriamycin/cyclophosphamide, followed by definitive surgery. The adaptive randomization engine preferentially assigns patients based upon cumulative performance of each agent in a given breast cancer subtype based on hormone receptor and HER2 receptor status.
J Mol Model
November 2024
Departamento de Química, División de Ciencias Básicas e Ingeniería, Universidad Autónoma Metropolitana-Iztapalapa, San Rafael Atlixco 186, Col, Vicentina, 09340, Iztapalapa, Ciudad de México, México.
Context: The monolayers of ethylene glycol and 2-hydroxyethoxide on gold surfaces have been used in hybrid materials as biosensors. In this article, the adsorption of ethylene glycol and 2-hydroxyethoxide on the Au(111) surface was analyzed. For the first system, ethylene glycol on Au(111), there are Au O and Au H interactions.
View Article and Find Full Text PDFCell Rep Med
November 2024
Department of Surgery, University of California, San Francisco, San Francisco, CA 94143, USA.
Only a subset of patients with breast cancer responds to immune checkpoint blockade (ICB). To better understand the underlying mechanisms, we analyze pretreatment biopsies from patients in the I-SPY 2 trial who receive neoadjuvant ICB using multiple platforms to profile the tumor microenvironment. A variety of immune cell populations and markers of immune/cytokine signaling associate with pathologic complete response (pCR).
View Article and Find Full Text PDFChemphyschem
October 2024
Faculty of Natural Sciences, Novosibirsk State University, 1 Pirogov str., Novosibirsk, 630090, Russia.
Since 1912 benzofuroxans have been believed to exhibit a molecular structure characterised by the presence of two fused rings, i. e. a benzene ring and a pentatomic heterocycle containing a N-O-N fragment wherein one of the two N atoms is involved in a further N O bond, namely benzo[1,2-c]1,2,5-oxadiazole N-oxide.
View Article and Find Full Text PDFJ Chem Phys
October 2024
Physical Sciences Division, Pacific Northwest National Laboratory, Richland, Washington 99354, USA.
The transformative impact of modern computational paradigms and technologies, such as high-performance computing (HPC), quantum computing, and cloud computing, has opened up profound new opportunities for scientific simulations. Scalable computational chemistry is one beneficiary of this technological progress. The main focus of this paper is on the performance of various quantum chemical formulations, ranging from low-order methods to high-accuracy approaches, implemented in different computational chemistry packages and libraries, such as NWChem, NWChemEx, Scalable Predictive Methods for Excitations and Correlated Phenomena, ExaChem, and Fermi-Löwdin orbital self-interaction correction on Azure Quantum Elements, Microsoft's cloud services platform for scientific discovery.
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