The total synthesis of hemiketal E (HKE) has been accomplished using a gold(I)-mediated cycloisomerization followed by oxidation of the enol ether product to introduce a unique keto-hemiketal, the core structure of HKE. Synthetic hemiketal E reproduced biosynthetically derived HKE in the inhibition of human platelet aggregation.
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| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6425725 | PMC |
| http://dx.doi.org/10.1021/acs.orglett.8b01578 | DOI Listing |
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