Smoking cessation treatment outcomes may be heavily influenced by genetic variations among smokers. Therefore, identifying specific variants that affect response to different pharmacotherapies is of major interest to the field. In the current study, we systematically review all studies published in or after the year 1990 which examined one or more gene-drug interactions for smoking cessation treatment. Out of 644 citations, 46 articles met the inclusion criteria for the systematic review. We summarize evidence on several genetic polymorphisms (CHRNA5-A3-B4, CYP2A6, DBH, CHRNA4, COMT, DRD2, DRD4 and CYP2B6) and their potential moderating pharamacotherarpy effects on patient cessation efficacy rates. These findings are promising and call for further research to demonstrate the effectiveness of genetic testing in personalizing treatment decision-making and improving outcome.
Download full-text PDF |
Source |
|---|---|
| http://www.ncbi.nlm.nih.gov/pmc/articles/PMC6219447 | PMC |
| http://dx.doi.org/10.2217/pgs-2018-0023 | DOI Listing |
Publication Analysis
Top Keywords
Similar Publications
Intranasal Calcitriol Accelerates Improvement of Sinonasal Inflammation and Olfactory Impairment in Mice After Cessation of Chronic Cigarette-Smoke Exposure.
Int Forum Allergy Rhinol
January 2025
Division of Division of Rhinology & Skull Base Surgery Department of Otolaryngology, University of Florida, Gainesville, Florida, USA.
Rationale: Smoking has been shown to be associated with circulating deficiencies in 25(OH)D3 and reduced sinonasal tissue levels of the active form of vitamin D, 1,25(OH)2D3. Given vitamin D's ability to reduce inflammation, we sought to examine if intranasal (IN) delivery of calcitriol [clinical analog of 1,25(OH)2D3] could reduce inflammation and improve disease severity in a murine model of chronic cigarette smoke-induced sinonasal inflammation (CS-SI).
Methods: Mice were exposed to CS 5 h/day, 5 days/week for 9 months, and then began IN calcitriol three times per week for 4 weeks.
Behavioral modification strategies for tobacco cessation: A scoping review.
J Educ Health Promot
November 2024
Department of Public Health Dentistry, ITS Centre for Dental Studies and Research, Murad Nagar, Ghaziabad - 201 206, Uttar Pradesh, India.
Tobacco use remains a global public health challenge, with numerous associated health risks. Behavioral modification strategies have played a pivotal role in helping individuals achieve and maintain tobacco cessation. This scoping review aims to compare different behavioral modifications for tobacco cessation counseling.
View Article and Find Full Text PDFPeriductal Mastitis Occurring Among Hubble-Bubble Smokers: A Report of Two Cases and Literature Review.
Cureus
December 2024
Department of Surgery, Arabian Gulf University, Manama, BHR.
Periductal mastitis (PM) is a form of nonlactational mastitis. The clinical picture varies from mild periareolar inflammation to frank retroareolar abscess formation. A huge amount of literature is incriminating cigarette smoking as a major contributing factor to the etiology of PM, and cessation of smoking is essential for a successful treatment.
View Article and Find Full Text PDFFactors Associated with Smoking Cessation of Participants in the National Lung Cancer Screening Program in Korea.
Cancer Res Treat
January 2025
Division of Cancer Early Detection, National Cancer Control Institute, National Cancer Center, Goyang, Korea.
Purpose: Smoking cessation interventions for participants in lung cancer screening are essential for increasing the effectiveness of screening to reduce lung cancer mortality. This study aimed to investigate the factors that lead to smoking cessation after lung cancer screening.
Materials And Methods: The Korean National Lung Cancer Screening (KNLCS) Satisfaction Survey was conducted from 2021 to 2022 with 1,000 samples per year among participants in KNLCS targets 30 or more pack-year smokers.
Eliciting Preferences for the Uptake of Smoking Cessation Apps: Discrete Choice Experiment.
J Med Internet Res
January 2025
Behavioural and Implementation Science Group, School of Health Sciences, University of East Anglia, Norwich, United Kingdom.
Background: If the most evidence-based and effective smoking cessation apps are not selected by smokers wanting to quit, their potential to support cessation is limited.
Objective: This study sought to determine the attributes that influence smoking cessation app uptake and understand their relative importance to support future efforts to present evidence-based apps more effectively to maximize uptake.
Methods: Adult smokers from the United Kingdom were invited to participate in a discrete choice experiment.
Want AI Summaries of new PubMed Abstracts delivered to your In-box?
Enter search terms and have AI summaries delivered each week - change queries or unsubscribe any time!