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Lifestyle behaviors and risk of cardiovascular disease and prognosis among individuals with cardiovascular disease: a systematic review and meta-analysis of 71 prospective cohort studies.
Int J Behav Nutr Phys Act
April 2024
Department of Health management, College of Public Health, Zhengzhou University, Zhengzhou, Henan, People's Republic of China.
Background: Healthy lifestyle behaviors (LBs) have been widely recommended for the prevention and management of cardiovascular disease (CVD). Despite a large number of studies exploring the association between combined LBs and CVD, a notable gap exists in integration of relevant literatures. We conducted a systematic review and meta-analysis of prospective cohort studies to analyze the correlation between combined LBs and the occurrence of CVD, as well as to estimate the risk of various health complications in individuals already diagnosed with CVD.
View Article and Find Full Text PDFStrategies for improving the performance of prediction models for response to immune checkpoint blockade therapy in cancer.
BMC Res Notes
April 2024
Department of Internal Medicine, University of Kentucky, 800 Rose St, Lexington, KY, 40536, USA.
Immune checkpoint blockade (ICB) therapy holds promise for bringing long-lasting clinical gains for the treatment of cancer. However, studies show that only a fraction of patients respond to the treatment. In this regard, it is valuable to develop gene expression signatures based on RNA sequencing (RNAseq) data and machine learning methods to predict a patient's response to the ICB therapy, which contributes to more personalized treatment strategy and better management of cancer patients.
View Article and Find Full Text PDFStrategies for Improving the Performance of Prediction Models for Response to Immune Checkpoint Blockade Therapy in Cancer.
medRxiv
July 2023
Department of Internal Medicine, University of Kentucky, Lexington, KY, US.
Immune checkpoint blockade (ICB) therapy holds promise for bringing long-lasting clinical gains for the treatment of cancer. However, studies show that only a fraction of patients respond to the treatment. In this regard, it is valuable to develop gene expression signatures based on RNA sequencing (RNAseq) data and machine learning methods to predict patients' response to the ICB therapy, which contributes to more personalized treatment strategy and better management of cancer patients.
View Article and Find Full Text PDFA role for artificial intelligence applications inside and outside of the operating theatre: a review of contemporary use associated with total knee arthroplasty.
Arthroplasty
July 2023
Discipline of Medical Specialties, University of Adelaide, Adelaide, SA, 5005, Australia.
Background: Artificial intelligence (AI) has become involved in many aspects of everyday life, from voice-activated virtual assistants built into smartphones to global online search engines. Similarly, many areas of modern medicine have found ways to incorporate such technologies into mainstream practice. Despite the enthusiasm, robust evidence to support the utility of AI in contemporary total knee arthroplasty (TKA) remains limited.
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