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http://dx.doi.org/10.7326/ACPJC-2018-168-12-065DOI Listing

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Exacerbations of persistent or intermittent asthma should be anticipated by physicians and health-care professionals. Patients who are likely to experience an exacerbation often have a history of an exacerbation in the previous year, and the absolute eosinophil count in peripheral blood is ≥ 400/μL. Similarly, expectorated or induced sputum eosinophilia of ≥2% is associated with exacerbations.

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Treatment strategies for the yellow zone.

Ann Allergy Asthma Immunol

October 2019

Rutgers New Jersey Medical School, The State University of New Jersey, Newark, New Jersey. Electronic address:

Objective: To evaluate relevant studies and documents that address treatment strategies for acute loss of asthma control (yellow zone).

Data Sources: Publications available on various treatment strategies for the yellow zone, Global Initiative for Asthma, and FDA Drug Safety Communication.

Study Selections: Studies that assessed the effectiveness of specific therapies as yellow zone strategies were included in this review.

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