AI Article Synopsis
- A new compound, kaemgalangol A, a seco-isopimarane, and 12 related compounds were extracted from the rhizomes of Kaempferia galanga.
- The identification of these compounds was achieved using various spectroscopic methods, including NMR and HRMS, while the structures of some were further confirmed through X-ray diffraction and electronic circular dichroism studies.
- Several of the isolated compounds showed cytotoxic effects against specific cancer cell lines, with notable inhibitory concentrations reported for three of them against HeLa and HSC-2 cells.
Article Abstract
A new unusual seco-isopimarane, kaemgalangol A (1) and 12 usual analogs (2-13) were isolated from the rhizomes of Kaempferia galanga (Family: Zingiberaceae). KaemgalangolA (1) represented a rarely isolated 9,10-seco-isopimarane skeleton. The chemical structures of the isolated compounds were mainlyinvestigated by spectroscopic techniques such as 1D, 2D NMR, and HRMS. The absolute configuration of 1-3 was studied by X-ray diffraction analysis as well as experimental and TDDFT-calculated electronic circular dichroism. Among the isolated diterpenoids, 5, 6 and 9 exhibited cytotoxic activity against HeLa (IC 75.1, 74.2 and 76.5 μM, respectively) and HSC-2 (IC 69.9, 53.3 and 58.2 μM, respectively) cancer cells.
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| http://dx.doi.org/10.1016/j.fitote.2018.06.010 | DOI Listing |
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