The aim of this paper is to present the autologous internal limiting membrane flap graft as a modification of the inverted flap technique in the surgical management of the full thickness macular hole. The 50-year old male admitted as an inpatient due to the full thickness macular hole was treated with 23G vitrectomy (Constellation). During the follow-up period his best corrected visual acuity improved significantly from 0.05 to 0.5. The optical coherence tomography confirmed the regeneration of the inner and outer retinal segments as well as of the internal limiting membrane. Autologous internal limiting membrane flap graft may be an alternative for cases of complicated full thickness macular holes and those patients in whom the conventional inverted flap technique cannot be used for various reasons.

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