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Aloperine Alleviates Atherosclerosis by Inhibiting NLRP3 Inflammasome Activation in Macrophages and ApoE Mice.
Curr Mol Pharmacol
January 2025
Department of Cardiology, Second Hospital of Shanxi Medical University, Taiyuan, Shanxi Province, 030001, China.
Background And Aims: Atherosclerosis is a chronic cardiovascular disease which is regarded as one of the most common causes of death in the elderly. Recent evidence has shown that atherosclerotic patients can benefit by targeting interleukin-1 beta (IL-1β). Aloperine (ALO) is an alkaloid which is mainly isolated from L.
View Article and Find Full Text PDFAloperine Attenuates UVB-induced Damage in Skin Fibroblasts via Activating TFE3/Beclin-1-Mediated Autophagy.
Protein Pept Lett
January 2025
Maternal and Child Research Institute, Shunde Women and Children's Hospital (Maternity and Child Healthcare Hospital of Shunde Foshan), Guangdong Medical University, Foshan, 528300, China.
Background: Aloperine (ALO) is an important active ingredient in the traditional Chinese medicinal plant Sophora alopecuroides L and has a significant autophagy-stimulating effect. The effect of ALO on cytotoxicity caused by UVB radiation in skin fibroblasts and the potential mechanism remains unclear.
Objective: The present study aimed to assess the effect of ALO on UVB-induced damage in skin fibroblasts and investigate its possible mechanism.
Article Synopsis
- Aloperine (ALO) shows potential as a treatment for acute liver injury caused by acetaminophen (APAP) through its protective effects observed in animal models.
- ALO administration before APAP exposure resulted in lower levels of damaging substances and reduced inflammation markers, indicating improved liver health.
- The study suggests that ALO works by inhibiting specific signaling pathways and inflammatory responses linked to liver damage.
Discovery of Aloperine as a Potential Antineoplastic Agent for Cholangiocarcinoma Harboring Mutant IDH1.
Int J Mol Sci
August 2024
Modern Research Center for Traditional Chinese Medicine, Key Laboratory of Chemical Biology and Molecular Engineering of Ministry of Education, Shanxi University, No. 92, Wucheng Road, Taiyuan 030006, China.
Intrahepatic cholangiocarcinoma (ICC) is a universally lethal malignancy with increasing incidence. However, ICC patients receive limited benefits from current drugs; therefore, we must urgently explore new drugs for treating ICC. Quinolizidine alkaloids, as essential active ingredients extracted from , can suppress cancer cell growth via numerous mechanisms and have therapeutic effects on liver-related diseases.
View Article and Find Full Text PDFAloperine protects the testis against testicular ischemia/reperfusion injury in rats.
Andrology
September 2024
Laboratory of Anesthesia and Critical Care Medicine, National-Local Joint Engineering Research Centre of Translational Medicine of Anesthesiology, West China Hospital, Sichuan University, Chengdu, Sichuan, China.
Background: Testicular torsion/detorsion can cause testis loss and infertility. Aloperine is a major active alkaloid extracted from Sophora alopecuroides Linn. It has been shown to have organ-protective effects.
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