Use of FEP flow reactor technology allows access to gram quantities of photochemically-generated tricyclic aziridines. These undergo a range of novel palladium-catalyzed ring-opening and cycloaddition reactions, likely driven by their inherent strain, allowing incorporation of further functionality by fusing additional heterocyclic rings onto these already complex polycyclic cores. This rapid, 2-step access to complex sp - rich heterocycles should be of interest to those in the fields of drug discovery and natural product synthesis.
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| http://dx.doi.org/10.1039/c5sc04062k | DOI Listing |
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